The theory of breast cancer as a <i>child deficiency disease</i> is an <i>inversion of the current paradigm</i>, which considers fullterm pregnancies to be a protective factor and uses nulliparous women as the reference group. Instead, the theory of breast cancer as a child deficiency disease says that women with the highest parity (about 20, which is the limit of human fertility) are those with ...

The thesis is based upon data from two cross-sectional population-based surveys, the SAMINOR 1 Survey (2003-2004) and the SAMINOR 2 Clinical Survey (2012-2014). The prevalence of pre-diabetes and diabetes mellitus among Sami and non-Sami inhabitants of the 24 municipalities from North- and Mid-Norway was estimated in the SAMINOR 1 Survey. No statistically significant difference in the prevalence of ...

Most sequence variants identified hitherto in genome-wide association studies (GWAS) of atrial fibrillation are common, non-coding variants associated with risk through unknown mechanisms. We performed a meta-analysis of GWAS of atrial fibrillation among 29,502 cases and 767,760 controls from Iceland and the UK Biobank with follow-up in samples from Norway and the US, focusing on low-frequency coding ...

<i>Aim</i>: To evaluate the availability and affordability of medicines used to treat of cardiovascular diseases (CVD) in several regions of the Russian Federation with different climatic, geographic, economic and demographic characteristics.<p> <p><i>Material and methods</i>: The study was conducted in 6 regional capitals, chosen to differ in geographically, economically, and demographically. ...

<p><i>Objectives - </i>To evaluate a modified Global Trigger Tool (GTT) method with manual review of automatic triggered records to measure adverse events. <p><i>Design - </i>A cross-sectional study was performed using the original GTT method as gold standard compared to a modified GTT method. <p><i>Setting - </i>Medium size hospital trust in Northern Norway. <p><i>Participants - </i>One thousand ...

<p><i>Objectives - </i>To investigate the impact of increasing sample of records reviewed bi-weekly with the Global Trigger Tool method to identify adverse events in hospitalised patients. <p><i>Design - </i>Retrospective observational study. <p><i>Setting - </i>A Norwegian 524-bed general hospital trust. <p><i>Participants - </i>1920 medical records selected from 1 January to 31 December ...

En god fastlegetjeneste er viktig, ikke minst der det er lang avstand til sykehus. I Nord-Norge er avstandene store, og gjennomsnittlig reisetid fra de 87 kommunesentra i Nord-Norge til nærmeste sykehus er 2 timer og 6 minutter. I denne artikkelen beskriver vi fastlegetjenesten i Nord-Norge samtidig som vi fokuserer på sentrale utfordringer som gjelder rekruttering av fastleger, det å få fastleger ...

<i>Background</i>: Due to limitations of conventional medicine for atopic eczema (AE), complementary and alternative medicine (CAM) is widely used as an alternative, maintaining, or simultaneous treatment for AE. We aimed to evaluate the beneficial and harmful effects of CAM for children with AE under 14 years old.<p> <p><i>Methods</i>: We searched for randomized trials on CAM in 12 Chinese and ...

<p><i>Background</i>: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.</p> <p><i>Methods</i>: We built two models, for ER+ (Model_ER+) and ER- tumors ...

<p><I>Introduction</I>: Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in men, while results of studies in women have been largely equivocal. We aimed to further examine the relationship between PA patterns and the risk of CRC in women, using ...