Institutt for samfunnsmedisin: Nye registreringer
Viser treff 1641-1660 av 2044
-
Major postoperative complications are associated with impaired long-term survival after gastro-esophageal and pancreatic cancer surgery: a complete national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-18)Background: Some studies have reported an association between complications and impaired long-term survival after cancer surgery. We aimed to investigate how major complications are associated with overall survival after gastro-esophageal and pancreatic cancer surgery in a complete national cohort. <br> Methods: All esophageal-, gastric- and pancreatic resections performed for cancer in Norway ... -
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-08)Background:<br> Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth ... -
Contamination index. A novel parameter for metal and pesticide analyses in maternal blood and umbilical cord
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07)PURPOSE:<br> To evaluate the contamination index of metals and pesticides in pregnant women, and to relate this to perinatal outcomes. <br> METHODS:<br> Descriptive, retrospective, exploratory study, developed from existing secondary data analyses at Level III maternity center. A total of 40 mothers with their newborns (NB), living in a rural area in Botucatu- Brazil and surrounding region. ... -
Priority setting for improvement of cervical cancer prevention in Iran
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-22)Background:<br> Cervical cancer is the fourth most common cancer among women worldwide. Organized cervical screening and vaccination against human papilloma virus (HPV) have been successful interventions for prevention of invasive cervical cancer (ICC). Because of cultural and religious considerations, ICC has low incidence in Iran and many other Muslim countries. There is no organized cervical ... -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-23)Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, ... -
Quantification of the smoking-associated cancer risk with rate advancement periods: Meta-analysis of individual participant data from cohorts of the CHANCES consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)Background:<br> Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking ... -
Modifiable causes of premature death in middle-age in Western Europe: Results from the EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-14)Background<br> Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death.<br> Methods<br> We analysed data from 264,906 European adults from the ... -
A method for sensitivity analysis to assess the effects of measurement error in multiple exposure variables using external validation data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-13)Background:<br>Measurement error in self-reported dietary intakes is known to bias the association between dietary intake and a health outcome of interest such as risk of a disease. The association can be distorted further by mismeasured confounders, leading to invalid results and conclusions. It is, however, difficult to adjust for the bias in the association when there is no internal validation ... -
Acute high-dose and chronic lifetime exposure to alcohol consumption and differentiated thyroid cancer: T-CALOS Korea
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-17)Background:<br> This study evaluated the effects of acute high-dose and chronic lifetime exposure to alcohol and exposure patterns on the development of differentiated thyroid cancer (DTC).<br> Methods:<br> The Thyroid Cancer Longitudinal Study (T-CALOS) included 2,258 DTC patients (449 men and 1,809 women) and 22,580 healthy participants (4,490 men and 18,090 women) who were individually ... -
“I Do Not Really Belong Out There Anymore”: Sense of Being and Belonging Among People With Medically Unexplained Long-Term Fatigue
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)In this article, we explore relations between health, being, belonging and place through an interpretive thematic analysis of autobiographic text and photographs about the everyday lives of 10 women and men living with medically unexplained long-term fatigue in Norway. While interpreting their place-related illness experiences, we ask: How do they experience their being in the world, where do they ... -
Life according to ME: Caught in the ebb-tide
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-01)In this article, we explore the role of ‘place’ in shaping people’s illness experiences through a data-led inductive case-study based on experiential data from people living with myalgic encephalomyelitis (ME) in Norway. Our main aim is to understand how they experience, interpret and attach meaning to various places in which they reside, and how they construct the course of a life influenced by ... -
Cystatin C and cardiovascular disease: a Mendelian randomization study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)BACKGROUND<br> Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.<br> OBJECTIVES<br>The aim of this study was to use Mendelian randomization ... -
Healthy lifestyle and risk of cancer in the European prospective investigation into cancer and nutrition cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04)It has been estimated that at least a third of the most common cancers are related to lifestyle and as such are preventable. Key modifiable lifestyle factors have been individually associated with cancer risk; however, less is known about the combined effects of these factors. This study generated a healthy lifestyle index score (HLIS) to investigate the joint effect of modifiable factors on ... -
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations.<br> Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ... -
External validation of prediction models for pneumonia in primary care patients with lower respiratory tract infection: An individual patient data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-26)Background:<br> Pneumonia remains difficult to diagnose in primary care. Prediction models based on signs and symptoms (S&S) serve to minimize the diagnostic uncertainty. External validation of these models is essential before implementation into routine practice. In this study all published S&S models for prediction of pneumonia in primary care were externally validated in the individual patient ... -
A Nested Case–Control Study of Metabolically Defined Body Size Phenotypes and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)Background:<br> Obesity is positively associated with colorectal cancer. Recently, body size subtypes categorised by the prevalence of hyperinsulinaemia have been defined, and metabolically healthy overweight/obese individuals (without hyperinsulinaemia) have been suggested to be at lower risk of cardiovascular disease than their metabolically unhealthy (hyperinsulinaemic) overweight/obese counterparts. ... -
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-08)Background:<br>Non-fatal outcomes of disease and injury increasingly detract from the ability of the world’s population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes aff ecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), ... -
Circulating Vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-04)Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs ... -
Diet quality scores and prediction of all-cause, cardiovascular and cancer mortality in a pan-european cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-13)Scores of overall diet quality have received increasing attention in relation to disease aetiol- ogy; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective ... -
Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01)Background:<br>Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.<br> Objectives:<br>We investigated the association between POPs and thyroid-stimulating hormone (TSH) ...