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dc.contributor.authorGjerde, Kristian Varden
dc.contributor.authorBartz-Johannessen, Christoffer
dc.contributor.authorSteen, Vidar Martin
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorSteen, Nils Eiel
dc.contributor.authorUeland, Thor
dc.contributor.authorLekva, Tove
dc.contributor.authorRettenbacher, Maria
dc.contributor.authorJoa, Inge
dc.contributor.authorReitan, Solveig Klæbo
dc.contributor.authorJohnsen, Erik
dc.contributor.authorKroken, Rune Andreas
dc.date.accessioned2024-10-07T13:20:55Z
dc.date.available2024-10-07T13:20:55Z
dc.date.issued2024-04-03
dc.description.abstractBackground - Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.<p> <p>Methods - The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.<p> <p>Results - The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.<p> <p>Conclusions - In our study, patients with schizophrenia – including the drug-naïve – have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.en_US
dc.identifier.citationGjerde, Bartz-Johannessen, Steen, Andreassen, Steen, Ueland, Lekva, Rettenbacher, Joa, Reitan, Johnsen, Kroken. Cellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disorders. Schizophrenia Research. 2024;267:223-229en_US
dc.identifier.cristinIDFRIDAID 2264924
dc.identifier.doi10.1016/j.schres.2024.03.029
dc.identifier.issn0920-9964
dc.identifier.issn1573-2509
dc.identifier.urihttps://hdl.handle.net/10037/35096
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalSchizophrenia Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleCellular adhesion molecules in drug-naïve and previously medicated patients with schizophrenia-spectrum disordersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)