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dc.contributor.authorFoscari, Aurelio Giovanni
dc.contributor.authorHerzke, Dorte
dc.contributor.authorMowafi, Riham
dc.contributor.authorSeiwert, Bettina
dc.contributor.authorDe Witte, Bavo
dc.contributor.authorDelbare, Daan
dc.contributor.authorHeras, Gustavo Blanco
dc.contributor.authorGago, Jesus
dc.contributor.authorReemtsma, Thorsten
dc.date.accessioned2025-07-07T11:35:30Z
dc.date.available2025-07-07T11:35:30Z
dc.date.issued2025-06-20
dc.description.abstractLittle is known about the exposure of aquatic biota to tire and road wear particles (TRWP) washed away from roads. Mussels were exposed for 7 days to model TRWP (m-TRWP), produced by milling tire tread particles with pure sand, and analyzed for 21 tire-related compounds by liquid chromatography-high resolution-mass spectrometry (LC-HRMS). Upon exposure to 0.5 g/L of m-TRWP, 15 compounds were determined from 944 μg/kg wet weight (diphenylguanidine, DPG) over 18 μg/kg for an oxidation product of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPDQ) to 0.6 μg/kg (4-hydroxydiphenyl amine). Transfer into mussels was highest for PTPD, DTPD and 6-PPDQ and orders of magnitude lower for 6-PPD. During 7 days depuration the concentration of all determined chemicals decreased to remaining concentrations between ~50 % (PTPD, DTPD) and 6 % (6-PPD). Suspect and non-target screening found 37 additional transformation products (TPs) of tire additives, many of which did not decrease in concentration during depuration, among them ten likely TPs of DPG, two of 6-PPD and PTPD and two of 1,2-dihydro-2,2,4-trimethylquinoline. A wide variety of chemicals is taken up by mussels upon exposure to m-TRWP and a wide range of TPs is formed, enabling the differentiation of biomarkers of exposure to TRWP and biomarkers of exposure to tire-associated chemicals.en_US
dc.identifier.citationFoscari, Herzke, Mowafi, Seiwert, De Witte, Delbare, Heras, Gago, Reemtsma. Uptake of chemicals from tire wear particles into aquatic organisms - search for biomarkers of exposure in blue mussels. Marine Pollution Bulletin. 2025;219en_US
dc.identifier.cristinIDFRIDAID 2390940
dc.identifier.doi10.1016/j.marpolbul.2025.118311
dc.identifier.issn0025-326X
dc.identifier.issn1879-3363
dc.identifier.urihttps://hdl.handle.net/10037/37447
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalMarine Pollution Bulletin
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2025 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleUptake of chemicals from tire wear particles into aquatic organisms - search for biomarkers of exposure in blue musselsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)