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    • Home, school, and community violence exposure and emotional and conduct problems among low-income adolescents: the moderating role of age and sex 

      Bordin, Isabel A; Handegård, Bjørn Helge; Paula, Cristiane S.; Duarte, Cristiane S.; Rønning, John Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-21)
      <p><i>Purpose - </i>The purpose of this study is to assess whether violence exposure is associated with emotional/conduct problems, when adjusting for confounders/covariates and controlling for comorbidity, and to investigate interactions between violence exposure and sex and/or age. <p><i>Methods - </i>This cross-sectional study evaluated a community-based sample of 669 in-school 11–15-year-olds. ...

    • Homeopati og bivirkninger 

      Stub, Trine (Chronicle; Kronikk, 2010)

    • Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer 

      Yndestad, Synnøve; Engebrethsen, Christina; Herencia-Ropero, A.; Nikolaienko, Oleksii; Vintermyr, Olav Karsten; Lillestøl, Reidun Kristine; Minsaas, Laura; Leirvaag, Beryl; Iversen, Gjertrud Titlestad; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Aase, Hildegunn Siv; Aas, Turid; Gudlaugsson, Einar; Llop-Guevara, Alba; Serra, Violeta; Janssen, Emiel; Lønning, Per Eystein; Knappskog, Stian; Eikesdal, Hans Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-01)
      Purpose - Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to assess the potential for PARPi in a wider group of patients with breast cancer.<p> <p>Methods - HRD status was established using targeted gene panel sequencing (360 genes) and ...

    • Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5) 

      Lindin, Inger; Wuxiuer, Yimingjiang; Kufareva, Irina; Abagyan, Ruben; Moens, Ugo; Sylte, Ingebrigt; Ravna, Aina Westrheim (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the groups of Houng Ni and Ligou New, and was found to be highly conserved throughout the vertebrates. Studies, both in vivo and in vitro, have shown that it is implicated in tumor ...

    • Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy 

      Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA esters, are used as pro-drugs to induce the formation of the potent photosensitizer protoporphyrin IX (PpIX). Activation of PpIX by light causes the formation of reactive oxygen species (ROS) and toxic responses. Studies have indicated that ...

    • Homology Modeling of Transporter Proteins 

      Sylte, Ingebrigt; Gabrielsen, Mari; Kristiansen, kurt (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological importance. Several presently used therapeutic compounds elucidate their effects by targeting membrane transporter proteins, including anti-arrhythmic, anesthetic, antidepressant, anxiolytic and diuretic drugs. The lack of three-dimensional structures of ...

    • Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus) 

      Mortensen, Åse-Karen; Mæhre, Silje; Kristiansen, kurt; Heimstad, Eldbjørg Sofie; Gabrielsen, Geir W.; Jenssen, Bjørn Munro; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-11)
      Thyroid hormone disrupting chemicals (THDCs) are of major concern in ecotoxicology. With the increased number of emerging chemicals on the market there is a need to screen for potential THDCs in a cost-efficient way, and <i>in silico</i> modeling is an alternative to address this issue. In this study homology modeling and docking was used to screen a list of 626 compounds for potential thyroid hormone ...

    • Hope and expectancies for future events in depression. 

      Thimm, Jens; Holte, Arne; Brennen, Tim; Wang, Catharina E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The present study investigated prospective cognition with the Hope scale (Snyder et al., 1991) and the Unrealistic Optimism Scale (Weinstein, 1980) in clinically depressed (CD; n = 61), previously depressed (PD; n = 42), and never depressed controls (ND; n = 46). In line with previous research, significant negative correlations between hope and symptoms of depression were found. Previously depressed ...

    • Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania 

      Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; Janice, Jessin; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the <i>bla</i><sub>CTX-M-15</sub> extended-spectrum-β-lactamase (ESBL) gene in <i>Klebsiella pneumoniae</i> isolates obtained from stool samples from hospitalized children and healthy controls ...

    • Horizontal transfer, selection and maintenance of antibiotic resistance determinants 

      Kloos, Julia Maria (Doctoral thesis; Doktorgradsavhandling, 2021-06-11)
      Scientific abstract Antibiotic resistance, especially in Gram-negative pathogens, represents a substantial clinical and financial burden to our society. The presented work investigated mechanisms and evolutionary dynamics that promote the emergence and maintenance of resistance in bacteria. In the first study, conserved collateral susceptibility changes were identified across resistant uropathogenic ...

    • Hormonal contraceptive use among Norwegian women before first childbirth 

      Jensen, Helene Marie Agejeva (Master thesis; Mastergradsoppgave, 2021-05-31)
      Introduction: Despite no major change in sexual debut, the total fertility rate in Norway has been declining over recent years. With perfect use, most modern contraceptive methods are effective to prevent conceptions. Hormonal contraceptive use is high among Norwegian women, suggesting high awareness of contraceptive behaviour and planned parenthood. This study aims to examine the contraceptive use ...

    • Hormonal contraceptive use in first and second interpregnancy intervals of Norwegian-born women 

      Johannessen, Martha Emilie (Master thesis; Mastergradsoppgave, 2021-05-31)
      Background and objective: Short interpregnancy intervals (IPIs) are associated with low birthweight and preterm births, while long IPIs may increase the risk of pre-eclampsia and small for gestational age (SGA). IPIs among Norwegian women are not described in the literature. The aim of this study is to investigate interpregnancy intervals and use of hormonal contraception between first and second ...

    • Hormonbehandling og hormonkonsentrasjon hos kvinner behandlet for eggstokkreft 

      Egeberg, Celine Victoria (Master thesis; Mastergradsoppgave, 2016-05-13)
      Epitelial eggstokkreft (EEK) er den 6. mest vanlige kreftformen blant norske kvinner. Det diagnostiseres ca. 450 nye tilfeller per år. Fem års overlevelse har økt og det har derfor vært viktig å se på langtidseffektene som påvirker kvinnene. Kvinnene kommer i en umiddelbar menopause etter kirurgisk fjerning av eggstokkene. Dette gjør også at de ofte opplever mer symptomer og plager enn kvinner som ...

    • Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty 

      Madsen, Andre; Bruserud, Ingvild Særvold; Bertelsen, Bjørn-Erik; Roelants, Mathieu; Oehme, Ninnie; Viste, Kristin; Bjerknes, Robert; Almås, Bjørg; Rosendahl, Karen; Mellgren, Gunnar; Sagen, Jørn V.; Juliusson, Petur Benedikt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-22)
      <p><i>Context - </i>Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. <p><i>Objective - </i>To ...

    • Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis 

      Waaseth, Marit; Bakken, Kjersti; Dumeaux, Vanessa; Olsen, Karina Standahl; Rylander, Charlotta; Figenschaug, Yngve; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-14)
      Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: ...

    • Hormone therapy use, sex hormone concentrations and gene expression : The Norwegian Women and Cancer study (NOWAC) 

      Waaseth, Marit (Doctoral thesis; Doktorgradsavhandling, 2010-08-27)
      I følge salgsstatistikken økte forbruket av hormontilskudd kraftig i Norge på 1990-tallet, men avtok fra 2002. Både hormontilskudd og kroppens egenproduserte kjønnshormoner er relatert til kreft hos kvinner, bl.a. brystkreft. Kreft karakteriseres ved ukontrollert celledeling som utvikles gradvis gjennom endringer i genmaterialet. Teknologisk utvikling gjør det mulig å utforske sammenhenger mellom ...

    • Hormonell prevensjon for menn – UiT-studenters holdninger. En spørreundersøkelse 

      Sævareid, Lillian Onstad (Master thesis; Mastergradsoppgave, 2022-05-27)
      Mens menn teknisk sett kan gjøre kvinner gravide 365 dager i året, kan kvinner kun bære fram barn én gang i løpet av et år. Likevel har det blitt sånn at de aller fleste prevensjonspreparater er utviklet for kvinner. Menn kan per i dag kun velge mellom kondom, som relativt ofte svikter, og sterilisering, som er invasivt og med usikker reversibilitet. Det forskes på hormonell prevensjon for menn, og ...

    • Hormones, smoking and mammographic density in postmenopausal Norwegian women : the Tromsø Mammography and Breast Cancer Study 

      Bremnes, Yngve (Doctoral thesis; Doktorgradsavhandling, 2007)
      Breast cancer is the most commonly occurring malignancy among women, and according to estimates by the International Agency for Research on Cancer, more than one million new cases were diagnoscd worldwide in 2002 (1). In Norway, altogether 2,780 women were diagnosed with breast cancer in 2005, corresponding to an age-adjusted (world) incidence rate of 75.7 per 100,000 women per year (2). According ...

    • Hospital stage of myocardial infarction treatment in 13 regions of Russian Federation by results of the international research 

      Kontsevaya, Anna V.; Bates, Katie; Goryachkin, Evgeny A.; Bobrova, Natalia; Syromiatnikova, Liudmila I.; Popova, Yulia V.; Platonov, Dmitry Yu.; Osipova, Irina V.; Nedbaikin, Andrei M.; Malorodova, Tatyana N.; Mirolyubova, Olga A.; Kryuchkov, Dmitry V.; Khaisheva, Larisa A.; Galyavich, Albert S.; Franz, Maria V.; Efanov, Alexey Yu.; Duplyakov, Dmitry V.; Drapkina, Oxana M.; Leon, David Adrew; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Aim</i>: To describe the characteristics of the patient with MI who is admitted to a hospital and to characterize the main diagnostic and treatment interventions in clinic.<p> <p><i>Material and methods</i>: This study is observational and the part of big international project. It includes a representative sample of patients with MI admitted to 16 clinics in 13 regions of Russian Federation ...

    • Hospitalization as a trigger for venous thromboembolism – Results from a population-based case-crossover study 

      Bjøri, Esben; Johnsen, Håkon Sandbukt; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-21)
      <i>Background</i> - Previous studies have reported that around 50% of patients with venous thromboembolism (VTE) has undergone recent hospitalization. However, studies on the impact of hospitalization as a trigger factor for VTE are limited.<p><p> <i>Objectives</i> - To investigate the impact of hospitalization with and without concurrent immobilization as a trigger factor for VTE.<p><p> ...