Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

The implementation of Electronic Health Records (EHRs) in developing countries is considered a means for improving data quality and high quality care. However, existing research, indicate that EHRs have recorded greater quantity of bad data instead of improving the quality of data. The reasons for this is not exactly clear. Accordingly, this paper takes a broader socio-technical approach to explore ...

Background Injuries are one of the leading causes of death worldwide. Bystanders at the scene can perform first aid measures before the arrival of health services. The quality of first aid measures likely affects patient outcome. However, scientifc evidence on its efect on patient outcome is limited. To properly assess bystander first aid quality, measure effect, and facilitate improvement, ...

<p>Background: The aim of this study was to train and assess firefighters’ skill attainment in the use of tourniquets, and to assess their skill retention after three months. The purpose is to show whether firefighters can successfully apply a tourniquet after a short course based on the new national recommendation for civilian prehospital tourniquet use. <p>Material and methods: This was a ...

Colon cancer is a common malignancy. We retrospectively established a biobank including 452 patients operated for colon cancer stage I-III in Northern Norway in the period 1998-2007. Tissue microarrays (TMAs) containing tumor tissue from these patients were constructed, and subsequently biomarker expression assessed by digital pathology. By using in situ hybridization, we assessed the expression of ...

<p><i>Background</i>: Nursing home residents often have several conditions that necessitate the use of multiple medicines. This study investigates the prevalence of potentially inappropriate medications (PIMs) and its associations with sex, age, number of medicines, and study location (rural/urban).</p> <p><i>Methods:</i> A cross-sectional study of long-term care residents from six nursing ...

Non-communicable diseases (NCDs) are prevalent, causing high rates of morbidity and mortality. A diet rich in fruit and vegetables are important in the prevention and management of NCDs. If-then plans is a planning strategy that could facilitate eating behaviour change by creating a mental link between a cue and a response in an “If…, then…”-structure. The aim was to investigate the effectiveness ...

Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ...

Store-and-forward telemedicine in resource-limited settings is becoming a relatively mature activity. However, there are few published reports about quality measurement in telemedicine, except in image-based specialties, and they mainly relate to high- and middle-income countries. In 2010, Médecins Sans Frontières (MSF) began to use a store-and-forward telemedicine network to assist its field staff ...

<i>Background</i> - It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated measurements, and to appraise the putative role of DNA methylation in the pathway between smoking and lung cancer development.<br><br> <i>Methods</i> - We derived a nested ...