Viser treff 1875-1894 av 10152

    • Cumulative risk of a false-positive screening result: A retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway 

      Tsuruda, Kaitlyn; Larsen, Marthe; Roman, Marta; Hofvind, Solveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)
      <p><b>Background</b> False-positive screening results are an inevitable and commonly recognized disadvantage of mammographic screening. This study estimated the cumulative probability of experiencing a first false-positive screening result in women attending 10 biennial screening rounds in BreastScreen Norway, which targets women aged 50 to 69 years. <p><b>Methods</b> This retrospective ...
    • Cupping therapy versus acupuncture for pain-related conditions: A systematic review of randomized controlled trials and trial sequential analysis 

      Zhang, Ya-Jing; Cao, Hui-Juan; Li, Xin-Lin; Yang, Xiao-Ying; Lai, Bao-Yong; Yang, Guo-Yang; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)
      Background: <br> Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies. <br> Objectives: <br> To compare the beneficial effectiveness and safety between cupping therapy and acupuncture for pain-related conditions to provide evidence ...
    • Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing 

      Ternullo, Selenia; Schulte Werning, Laura; Holsæter, Ann Mari; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)
      A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound ...
    • Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment 

      Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component ...
    • Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network 

      Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan R.; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J.H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Kateřina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-18)
      Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption ...
    • Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers 

      Grindedal, Eli Marie; Heramb, Cecilie; Karsrud, Inga; Ariansen, Sarah Louise; Mæhle, Lovise Olaug; Undlien, Dag Erik; Norum, Jan; Schlichting, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-21)
      Background: <br> Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. However, there is limited knowledge of the sensitivity of such a strategy, and of the clinical aspects of BC caused by BRCA mutations in less selected BC cohorts. The aim ...
    • Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities 

      Tiller, Heidi; Husebekk, Anne; Ahlen, Maria Therese; Stuge, Tor Brynjar; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-19)
      Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological ...
    • Current situation and future opportunity of telemedicine in Bangladesh 

      Kalam, Abul (Master thesis; Mastergradsoppgave, 2011-08-15)
      Developing countries are leisurely adopter of new technologies, particularly with regards to the health services of these countries. This study explores the current health information infrastructure and future prospects of information and communication technology in health system of Bangladesh using an interpretative case study approach and proposes apply Telemedicine system to ensure health for ...
    • Current situation of paediatric chronic pain in Switzerland: prevalence and paediatricians’ experiences. A cross-sectional study 

      Carlander, Maria (Master thesis; Mastergradsoppgave, 2019-07-10)
      <p><i>Background:</i> Chronic pain (CP) prevalence in children and adolescents has been increasing over the past decades. The patient-reported prevalence is around 25% depending on the methodology and location of pain. Chronic pain is defined in this study as persisting or recurrent pain that has lasted longer than three months. <p><i>Objectives:</i> To estimate the prevalence of chronic pain in ...
    • Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies 

      Tellez Gabriel, Marta; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ...
    • Current status of rehabilitation activity and the new health care reform in Norway 

      Tingvoll, Wivi-Ann; McClusky, Leon (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-02)
      The purpose of this study is to analyse the current activities of Norwegian ambulatory rehabilitation teams at a time when the field of rehabilitation is set for major changes with the recent introduction of the new pro-rehabilitation Coordination Reform. The content of the all logged consultations of four ambulatory teams belonging to one of the four regional health authorities was analysed ...
    • Curriculum factors influencing knowledge of communication skills among medical students 

      Bærheim, Anders; Anvik, Tor; Risberg, Terje; Hjortdahl, Per; Holen, Are; Fasmer, Ole Bernt; Grimstad, Hilde; Gude, Tore; Vaglum, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-10-10)
      Background: Communication training builds on the assumption that understanding of the concepts related to professional communication facilitates the training. We know little about whether students' knowledge of clinical communication skills is affected by their attendance of communication training courses, or to what degree other elements of the clinical training or curriculum design also play a ...
    • Cut-off values of serum potassium and core temperature at hospital admission for extracorporeal rewarming of avalanche victims in cardiac arrest: A retrospective multi-centre study 

      Brugger, Hermann; Bouzat, Pierre; Pasquier, Mathieu; Mair, Peter; Fieler, Julia; Darocha, Tomasz; Blancher, Marc; de Riedmatten, Matthieu; Falk, Markus; Paal, Peter; Strapazzon, Giarcome; Zafren, Ken; Maeder, Monika Brodmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06)
      Aim: Evidence of existing guidelines for the on-site triage of avalanche victims is limited and adherence suboptimal. This study attempted to find reliable cut-off values for the identification of hypothermic avalanche victims with reversible out-of-hospital cardiac arrest (OHCA) at hospital admission. This may enable hospitals to allocate extracorporeal life support (ECLS) resources more appropriately ...
    • Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia. 

      Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Computations of placebo effects are essential in randomized controlled trials (RCTs) for separating the specific effects of treatments from unspecific effects associated with the therapeutic intervention. Thus, the identification of placebo responders is important for testing the efficacy of treatments and drugs. The present study uses data from an experimental study on placebo analgesia to suggest ...
    • Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns 

      Bhattacharya, Debashish; Haugen, Peik; Palmer, Jeffrey D.; Turner, Seán; Lewis, Louise A.; Pryer, Kathleen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-09-08)
      Background: Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other ...
    • Cyberbullying status and mental health in Norwegian adolescents 

      Kaiser, Sabine; Kyrrestad, Henriette; Fossum, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)
      The aim of the present study was to examine how the cyberbullying status (not involved, cyber‐victim only, cyberbully only, cyber‐victim and bully) is related to the mental health of the adolescents when controlled for traditional bullying experience. We also examined the potential moderator sex on the relationship between cyberbullying status and mental health. Univariate analyses of variance were ...
    • Cyclic nucleotide dependent ATPase activity in inside out vesicles from human erythrocytes 

      Rafiq, Sarah (Master thesis; Mastergradsoppgave, 2015-01-27)
      The transport of cyclic nucleotides out of the cell is energy requiring, dependent on ATP- hydrolysis. The ability to stimulate this ATPase is a hallmark of substrates for ABC-transporters e.g. ABCC5, ABCC4. It is believed that ABCC5 transporter has selective high affinity for cGMP. Previous studies support the idea that ABCC5 contribute to cGMP transport by human erythrocytes. Human erythrocyte ...
    • Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs 

      Ben-Batalla, Isabel; Cubas-Cordova, Miguel; Udonta, Florian; Wroblewski, Mark; Waizenegger, Jonas S.; Janning, Melanie; Sawall, Stefanie; Gensch, Victoria; Zhao, Lin; Martinez, Inigo Zubiavrre; Riecken, Kristoffer; Fehse, Boris; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
      Anti-angiogenic therapies were approved for different cancers. However, significant primary and secondary resistance hampers efficacy in several tumor types including breast cancer. Thus, we need to develop clinically applicable strategies to enhance efficacy of anti-angiogenic drugs. We report that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product ...
    • Cyclophosphamide effect on immunoglobulins levels in AAV patients treated with long-term pre-emptive rituximab maintenance. 

      Besada, Emilio; Koldingsnes, Wenche; Nossent, Johannes C (Conference object; Konferansebidrag, 2013)
    • Cystatin C and cardiovascular disease: a Mendelian randomization study 

      van der Laan, Sander W; Fall, Tove; Sourmare, Aicha; Teumer, Alexander; Sedaghat, Sanaz; Baumert, Jens; Zahaneh, Delilah; van Setten, Jessica; Isgum, Ivana; Galesloot, Tessel E.; Arpegård, Johannes; Amouyel, Philippe; Trompet, Stella; Waldenberger, Melanie; Dörr, Marcus; Magnusson, Patrik K.; Giedraitis, Vilmantas; Larsson, Anders; Morris, Andrew P.; Felix, Janine F.; Morrison, Alanna C.; Franceschini, Nora; Bis, Joshua C.; Kavousi, Maryam; O'Donnell, Christopher J.; Drenos, Fotios; Tragante, Vinicius; Munroe, Patricia B.; Malik, Rainer; Dichgans, Martin; Worrall, Bradford B.; Erdmann, Jeanette; Nelson, Christopher P.; Samani, Nilesh J.; Schunkert, Heribert; Marchini, Jonathan; Patel, Riyaz S.; Hingorani, Aroon D.; Lind, Lars; Pedersen, Nancy L.; de Graaf, Jacqueline; Kiemeney, Lambertus A.L.M.; Baumeister, Sebastian E.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Koenig, Wolfgang; Meisinger, Christa; Peters, Annette; Thorand, Barbara; Jukema, J.Wouter; Eriksen, Bjørn Odvar; Toft, Ingrid; Wilsgaard, Tom; Onland-Moret, N. Charlotte; van der Schouw, Yvonne T.; Debette, Stéphanie; Kumari, Meena; Svensson, Per; van der Harst, Pim; Kivimäki, Mika; Keating, Brendan J.; Sattar, Naveed; Dehghan, Abbas; Reiner, Alex P.; Ingelsson, Erik; Den Ruijter, Hester M.; de Bakker, Paul I.W.; Pasterkamp, Gerard; Ärnlöv, Johan; Holmes, Michael V.; Asselbergs, Folkert W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)
      BACKGROUND<br> Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation.<br> OBJECTIVES<br>The aim of this study was to use Mendelian randomization ...