Browsing Det helsevitenskapelige fakultet by Title

Now showing items 3270-3289 of 10152

    • Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer 

      Johannessen, Charles; Moi, Line; Kiselev, Yury; Pedersen, Mona Irene; Dalen, Stig Manfred; Braaten, Tonje; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-26)
      MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and are dysregulated in cancer. Studies of miRNAs to explore their potential as diagnostic and prognostic markers are of great scientific interest. Here, we investigate the functional properties and expression of the miR-143/145 cluster in breast cancer (BC) in vitro and in vivo. The ER ...

    • Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines 

      Johannessen, Charles Walquist (Doctoral thesis; Doktorgradsavhandling, 2019-03-01)
      MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) involved in the regulation of gene expression, and they are often seen dysregulated in cancer. For this reason, it is of great scientific interest to study these ncRNAs to better understand their distribution in human tissues and their mode of function. Based on a comprehensive miRNA microarray from 108 breast cancers in the Norwegian Woman and ...

    • Expression and functions of long non-coding RNA NEAT1 and isoforms in breast cancer 

      Knutsen, Erik; Harris, Adrian; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-20)
      NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential scaffold for the assembly of a class of nuclear ribonucleoprotein bodies called paraspeckles. Paraspeckle formation is elevated by a wide variety of cellular stressors and in certain developmental processes, either through transcriptional ...

    • Expression of adenylyl cyclase subtypes in endocrine pancreatic cell lines 

      Krum-Hansen, Sanda (Master thesis; Mastergradsoppgave, 2003-09)

    • Expression of G-Protein βγ Subunits in Endocrine Pancreatic cell Lines 

      Baug, Therese (Master thesis; Mastergradsoppgave, 2004-09)

    • The expression of miR-21 in prostate cancer measured by in situ hybridization and its relevance as a diagnostic biomarker 

      Melbø-Jørgensen, Christian Nordahl (Master thesis; Mastergradsoppgave, 2012-12-15)
      Background: Micro RNAs (miRNA) are a novel class of molecular regulators that have gained considerable attention in cancer research. Multiple studies in recent time have reported altered miRNA regulation in most cancers by deregulating of oncogenes and tumour suppressor genes. Additionally, certain tumours are represented by specific miRNA expression files. Prostate cancer is a markedly heterogeneous ...

    • Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study 

      Stikbakke, Einar; Wilsgaard, Tom; Haugnes, Hege Sagstuen; Pedersen, Mona Irene; Knutsen, Tore; Støyten, Martin; Giovannucci, Edward; Eggen, Anne Elise; Thune, Inger; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-23)
      The role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (n = 189). ...

    • Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy 

      Sletten, Elise Thoresen; Smaglyukova, Natalia; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)
      The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after ...

    • Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer 

      Andersen, Sigve; Richardsen, Elin; Rakaee, Mehrdad; Bertilsson, Helena; Bremnes, Roy; Børset, Magne; Busund, Lill-Tove; Slørdahl, Tobias (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-30)
      Background: Prostate cancer (PC) stratification needs new prognostic tools to reduce overtreatment. Phosphatase of regenerating liver (PRL-3) is a phosphatase found at high levels in several cancer types, where its expression is associated with survival. A recent PC cell line study has shown it to be involved in PC growth and migration. <br>Methods: We used a monoclonal antibody to evaluate ...

    • Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Lund-Iversen, Marius; Berge, Gisle; Brustugun, Odd Terje; Solberg, Steinar; Mælandsmo, Gunhild; Pedersen, Kjetil Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. Four NSCLC cell lines were treated ...

    • The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers 

      Knutsen, Erik; Lellahi, Seyed Mohammad; Aure, Miriam Ragle; Nord, Silje; Fismen, Silje; Larsen, Kenneth Bowitz; Tellez Gabriel, Marta; Hedberg, Annica; Bjørklund, Sunniva; Bofin, Anna M.; Mælandsmo, Gunhild Mari; Sørlie, Therese; Mortensen, Elin Synnøve; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-28)
      The long non-coding RNA <i>NEAT1</i> locus is transcribed into two overlapping isoforms, <i>NEAT1_1</i> and <i>NEAT1_2</i>, of which the latter is essential for the assembly of nuclear paraspeckles. <i>NEAT1</i> is abnormally expressed in a wide variety of human cancers. Emerging evidence suggests that the two isoforms have distinct functions in gene expression regulation, and recently it was shown ...

    • The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma 

      Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Mingo, Janire; Øyjord, Tove Ragnhild; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Errarte, Peio; Larrinaga, Gorka; Llarena, Roberto; López, José I.; Pulido, Rafael (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-05)
      Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation. We studied the expression and activity of pyruvate dehydrogenase kinases (PDK1-4), key enzymes of the energy metabolism, in renal cancer cells. We analysed the expression, subcellular distribution and clinicopathological correlations ...

    • Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis 

      Böhm, Julia K.; Schaeben, Victoria; Schäfer, Nadine; Güting, Helge; Lefering, Rolf; Thorn, Sophie; Schöchl, Herbert; Zipperle, Johannes; Grottke, Oliver; Rolf, Rossaint; Stanworth, Simon; Curry, Nicola; Maegele, Marc; Åkerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Vik, Anne; Anke, Audny Gabriele Wagner; Antoni, Anna; Audibert, Gérard; Azouvi, Philippe; Frisvold, Shirin; Skandsen, Toril; Helseth, Eirik; Røe, Cecilie; Røise, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Background Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with high rates of complications, unfavorable outcomes, and mortality. The underlying mechanisms are largely unknown. Embedded in the prospective multinational Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, coagulation profiles beyond standard conventional ...

    • Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae 

      Søraas, Arne Vasli Lund; Olsen, Ingar; Sundsfjord, Arnfinn; Handal, Trude; Bjørang, Ola; Jenum, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Extended-spectrum β-lactamases and carbapenemases in clinical isolates of Enterobacteriaceae in Norway. Aspects of detection and epidemiology. 

      Tofteland, Ståle (Doctoral thesis; Doktorgradsavhandling, 2015-04-16)

    • Extending the EQ-5D: the case for a complementary set of 4 psycho-social dimensions 

      Chen, Gang; Olsen, Jan Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-20)
      Objectives - The EQ-5D is the most widely applied preference-based health-related quality of life measure. However, concerns have been raised that the existing dimensional structure lacks sufficient components of mental and social aspects of health. This study empirically explored the performance of a coherent set of four psycho-social bolt-ons: Vitality; Sleep; Personal relationships; and Social ...

    • Extending the usefulness of the verbal memory test: The promise of machine learning 

      Chandler, Chelsea; Holmlund, Terje Bektesevic; Foltz, Peter W.; Cohen, Alex S.; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      The evaluation of verbal memory is a core component of neuropsychological assessment in a wide range of clinical and research settings. Leveraging story recall to assay neurocognitive function could be made more useful if it were possible to administer frequently (i.e., would allow for the collection of more patient data over time) and automatically assess the recalls with machine learning methods. ...

    • Extent of Preoperative False Lumen Thrombosis Does Not Influence Long-Term Survival in Patients With Acute Type A Aortic Dissection 

      Larsen, Magnus; Bartnes, Kristian; Tsai, TT; Eagle, KA; Evangelista, Arturo; Nienaber, CA; Suzuki, Toru; Fattori, Rossella; Forehlich, James B; Hutchinson, Stuart J.; Sundt, Thoralf M.; Januzzi, James L.; Isselbacher, Eric M.; Montgomery, Daniel G.; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background-—Partial thrombosis of the false lumen has been related to aortic growth, reoperations, and death in the chronic phase of type B and repaired type A aortic dissections. The impact of preoperative false lumen thrombosis has not been studied previously. We used data from a contemporary, multinational database on aortic dissections to evaluate whether different degrees of preoperative ...

    • Extent, Awareness and Perception of Dissemination Bias in Qualitative Research: An Explorative Survey 

      Toews, Ingrid; Glenton, Claire; Lewin, Simon; Berg, Rigmor C.; Noyes, Jane; Booth, Andrew; Marusic, Ana; Malicki, Mario; Munthe-Kaas, Heather M.; Meerpohl, Joerg J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-03)
      <b>Background</b> <br> Qualitative research findings are increasingly used to inform decision-making. Research has indicated that not all quantitative research on the effects of interventions is disseminated or published. The extent to which qualitative researchers also systematically underreport or fail to publish certain types of research findings, and the impact this may have, has received ...

    • Extent, regional variation and impact of gynecologist payment models in routine pelvic examinations: A nationwide cross-sectional study 

      Rosenlund, Ingvild Mathiesen; Leivseth, Linda; Nilsen, Ingard; Førde, Olav Helge; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-21)
      <p><i>Background - </i> Based on moderate quality evidence, routine pelvic examination is strongly recommended against in asymptomatic women. The aims of this study was to quantify the extent of routine pelvic examinations within specialized health care in Norway, to assess if the use of these services differs across hospital referral regions and to assess if the use of colposcopy and ultrasound ...