Browsing Det helsevitenskapelige fakultet by Title

Now showing items 3846-3865 of 10152

    • Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis 

      Tveita, Anders Aune; Rekvig, Ole Petter; Zykova, Svetlana N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-01)
      Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex deposition. It has been speculated that alterations in the synthesis or ...

    • Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro 

      Reine, Trine M.; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-23)
      <b>Purpose:</b> Glucosamine (GlcN) supplements are promoted for medical reasons, for example, for patients with arthritis and other joint-related diseases. Oral intake of GlcN is followed by uptake in the intestine, transport in the circulation and thereafter delivery to chondrocytes. Here, it is postulated to have an effect on synthesis and turnover of extracellular matrix constituents expressed ...

    • Glucose metabolism, genetic factors, vitamin D binding protein and directly measured free 25-hydroxyvitamin D -Results from a randomized controlled trial with high-dose vitamin D supplementation in subjects with prediabetes 

      Sollid, Stina Therese (Doctoral thesis; Doktorgradsavhandling, 2016-04-21)
      Tidligere studier har vist en sammenheng mellom vitamin D-nivåer og type 2 diabetes, men om vitamin D kan brukes for å forebygge type 2 diabetes, har ikke vært kjent. 511 personene ble inkludert i studien og jevnt fordelt til å motta enten ukentlig høy-dose vitamin D-tilskudd eller narremedisin (placebo). Etter ett år var det ingen effekt av vitamin D-tilskudd på utviklingen av type 2 diabetes ...

    • Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 

      Grinde, Maria Tunset; Hilmarsdòttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads Haugland; Rye, Morten Beck; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Introduction - </i>Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently undergoing clinical trials in several human malignancies, including triple-negative breast cancer ...

    • Glyphosate non-toxicity: the genesis of a scientific fact 

      Cuhra, Marek (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-30)
      Repetition of a 1978 experiment on the toxicity of glyphosate chemicals in water-flea Daphnia magna showed surprising results. In the 31 years which had passed between the two series of experiments, the toxicity of glyphosate had apparently become 300 times stronger! Further investigation into this enigmatic paradox discloses unfortunate aspects of laboratory researcher cultures as well as fundamental ...

    • Glyphosate-Residues in Roundup-Ready Soybean Impair Daphnia magna Life-Cycle 

      Cuhra, Marek; Traavik, Terje; Dando, Mickael; Primicerio, Raul; Holderbaum, Daniel Ferreira; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-30)
      Herbicide tolerant plants such as Roundup-Ready soybean contain residues of glyphosate herbicide. These residues are considered safe and previous animal-feeding-studies have failed to find negative effects related to such chemical residues. The present study tests 8 experimental soy- meal diets as feed in groups (each containing 20 individuals) of test-animals (D. magna). The diets have different ...

    • Glyphosate: too much of a good thing? 

      Cuhra, Marek; Bøhn, Thomas; Cuhra, Petr (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-28)
      Although previously accepted as the less toxic alternative, with low impact on animals, farmers as well as consumers who are exposed to residues in food, glyphosate chemicals are now increasingly controversial as new evidence from research is emerging. We argue that specific aspects of the history, chemistry and safety of glyphosate and glyphosate-based herbicides should be thoroughly considered ...

    • Gode barnevernsinstitusjoner: en systematisk kartleggingsoversikt 

      Johansen, Trine Bjerke; Jardim, Patricia Sofia Jacobsen; Blaasvær, Nora; Ames, Heather Melanie R; Munthe-Kaas, Heather Eileen Menzies; Tingulstad, Alexander; Berg, Rigmor (Research report; Forskningsrapport, 2020-06-10)
      Vi undersøkte hva forskning fra 2010-2019 sier om tiltak, metoder og strategier som skal legge til rette for god omsorg for barn og unge i barnevernsinstitusjoner.

    • Gode helseregistre - bedre helse : handlingsplan 2014-2015 

      Dahl, Cathrine; Hagen, Elisabeth; Magnus, Trine; Stensland, Eva (Research report; Forskningsrapport, 2014)
      Arbeidet med modernisering og samordning av de sentrale helseregistrene og de medisinske kvalitetsregistrene er godt i gang. Det har gitt viktige og synlige resultater for feltet. Det er blant annet etablert til sammen 47 nasjonale medisinske kvalitetsregistre og en felles resultattjeneste for disse. Det nye Hjerte- og karregisteret ble åpnet i Bergen i 2012. Norsk pasientregister er videreutviklet ...

    • Gode pasientløp i terminal omsorg og kreftbehandling i kommunehelsetjenesten : en evaluering 

      Harboe-Sjåvik, Hege (Master thesis; Mastergradsoppgave, 2012-06-01)
      Arbeidet med oppgaven har foregått som prosessevaluering av gjennomføring av Brobyggerprosjektet; et prosjekt som har vært utført i regi av Båtsfjord kommune i 2010-2012, med bedring av pasientløp og omsorg for terminale kreftpasienter i kommunen som de overordnede prosjektmål. Prosessevalueringen er gjort gjennom å følge prosessen ved gjennomføring av prosjektet fortløpende, og å evaluere gjennomføringen ...

    • Godt arbeidsmiljø-leders ansvar? 

      Barstad, Mari Anne Skåtun (Master thesis; Mastergradsoppgave, 2010-08-01)
      Økning av sykefravær er et stort problem i dagens samfunn, og vi vet for lite om årsaken til dette. Arbeidsplassen er et sted hvor man tilbringer mye av sin tid, og faktorer der vil ha betydning for trivsel som igjen har innvirkning på helse og sykefravær. Forhold til leder viser seg å bety mye for om en trives og får utvikle seg faglig. Høyt nivå av stress på jobben kombinert med liten medbestemmelse ...

    • "Et godt lokalt læringsmiljø?": erfaringer med desentralisert bachelor i sykepleie, i tre kommunale studentgrupper 2001-2004. Rapport fra pilotprosjektet med ny desentralisert modell 

      Blix, Siv; Eriksen, Liss (Research report; Forskningsrapport, 2012)

    • Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model 

      Ternullo, Selenia; de Weerd, Louis; Holsæter, Ann Mari; Flaten, Gøril Eide; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel, 2017-09-12)
      Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). ...

    • Gonadotrophin - releasing hormone analogues for endometriosis: bone mineral density 

      Sagsveen, Mette (Master thesis; Mastergradsoppgave, 2003)

    • Good feelings and increased job performance : pleasure and interest as predictors of skill improvement and work achievement among Norwegian job-holders 

      Warholm, Vegard Stokka (Master thesis; Mastergradsoppgave, 2010-05-14)
      Research within neurobiology has provided evidence for two distinctive classes of positive emotion, represented by separate brain systems called the “reward seeking-” (appetitive) and the “pleasure-” (consummatory) system (Burgdorf & Panksepp 2006). Recently, happiness research has provided empirical evidence for a distinction between the emotions “interest” and “pleasure” (Vittersø, Overwien & ...

    • Good lives : exploring the dynamics of emotions and motivation in outdoor recreation 

      Søholt, Yngvil (Master thesis; Mastergradsoppgave, 2008-05)
      The purpose of this study was threefold: First, to analyze some core concepts of human well-being. As part of this issue, the study deals with the distinction between life satisfaction and personal growth. Also related to this first issue, the study investigates the difference between the emotion of pleasure and the emotion of interest. Second, to investigate changes in health, life satisfaction and ...

    • GP decisions to participate in emergencies: a randomised vignette study 

      Hjortdahl, Magnus; Gyrd-Hansen, Dorte; Halvorsen, Peder Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      <i>Background</i> - GPs use their judgement on whether to participate in emergencies; however, little is known about how GPs make their decisions on emergency participation.<p> <p><i>Aim</i> - To test whether GPs' participation in emergencies is associated with cause of symptoms, distance to the patient, other patients waiting, and out-of-hours (OOH) clinic characteristics.<p> <p><i>Design & ...

    • GP utilisation by education level among adults with COPD or asthma: A cross-sectional register-based study 

      Hetlevik, Øystein; Melbye, Hasse; Gjesdal, Sturla (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-09)
      There is a marked socioeconomic gradient in the prevalence of chronic obstructive pulmonary disease (COPD) and asthma, but a large proportion of patients remain undiagnosed. It is a challenge for general practitioners (GPs) to both identify patients and contribute to equity and high quality in services delivered. The aim of this study was to identify patients with COPD and asthma diagnoses recorded ...

    • GP-confirmed complete Achilles tendon rupture using pocket-sized ultrasound: a case report 

      Davis, Simon; Lott, Alexander; Besada, Emilio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
      The incidence of complete Achilles tendon rupture is 18 per 100 000 patient-years and is usually diagnosed clinically by GPs. The extent of clinical misdiagnosis is unknown in Norway, but may be high. This is important as delayed treatment has unfavourable consequences. We report how a GP, with no clinical ultrasound experience, recorded images with a pocket-sized ultrasound device (PSUD) under ...

    • GPs' decision-making - perceiving the patient as a person or a disease 

      Andre, M; Anden, A; Borgquist, L; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background: The aim of this study was to analyse the clinical decision making strategies of GPs with regard to the whole range of problems encountered in everyday work. Methods: A prospective questionnaire study was carried through, where 16 General practitioners in Sweden registered consecutively 378 problems in 366 patients. Results: 68.3% of the problems were registered as somatic, 5.8% as ...