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Now showing items 4104-4123 of 10152
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High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ... -
High levels of incidental physical activity are positively associated with cognition and EEG activity in aging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-25)High levels of physical activity seem to positively influence health and cognition across the lifespan. Several studies have found that aerobic exercise enhances cognition and likely prevents cognitive decline in the elderly. Nevertheless, the association of incidental physical activity (IPA) with health and cognition during aging has not been studied. Thus, the aim of this study was to evaluate the ... -
High levels of multiresistance in quinolone resistant urinary tract isolates of Escherichia coli from Norway; a non clonal phenomen?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
High miR-205 expression in normal epithelium is associated with biochemical failure - An argument for epithelial crosstalk in prostate cancer?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)Due to insufficient prognostic tools, failure to predict aggressive prostate cancer (PC) has left patient selection for radical treatment an unsolved challenge. This has resulted in overtreatment with radical therapy. Better prognostic tools are urgently warranted. MicroRNAs (miRs) have emerged as important regulators of cellular pathways, resulting in altered gene expressions. miR-205 has previously ... -
High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted ... -
High Palmitate Alters Glutathione Redox During Severe Oxidant Stress in the Heart; An Evaluation of Altered Glutathione Redox Environment on Cardiac Function and Mitochondrial Energetics.
(Mastergradsoppgave; Master thesis, 2021-05-18)When the heart is under stress, e.g. ischemia-reperfusion (IR), it produces an enormous amount of reactive oxygen species (ROS). Glutathione, which is an endogenous antioxidant derived from the ‘nicotinamide adenine dinucleotide hydrogen’ (NADH) of the ‘tricarboxylic acid’ cycle, can fight against this oxidative stress to balance the redox environment, and convert the produced ROS to H2O. In this ... -
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background - C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays.<p> <p>Methods - ... -
High prevalence of chronic musculoskeletal complaints among women in a Norwegian general population: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established ... -
The high prevalence of low HDL-cholesterol levels and dyslipidemia in rural populations in Northwestern China
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-07)Background<p> <p>Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. This study aimed to describe the prevalence of dyslipidemia and low high density lipoprotein cholesterol (HDL-cholesterol) and associated risk factors among adults in rural northwest China.<p> Methods<p> <p>In a cross-sectional analyses involving 2,980 adults ... -
High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were ... -
High prevalence of multidrug resistant ESBL- and plasmid mediated AmpC-producing clinical isolates of Escherichia coli at Maputo Central Hospital, Mozambique
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-06)Background: Epidemiological data of cephalosporin-resistant Enterobacterales in Sub-Saharan Africa is still restricted,and in particular in Mozambique. The aim of this study was to detect and characterize extended-spectrum β-lactamase (ESBL) - and plasmid-mediated AmpC (pAmpC)-producing clinical strains of Escherichia coli at Maputo Central Hospital (MCH), a 1000-bed reference hospital in Maputo, ... -
High prevalence of overweight and obesity among 6-year-old children in Finnmark County, North Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012) -
High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)<p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with ... -
High progesterone receptor expression in prostate cancer is associated with clinical failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-27)Background Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the ... -
High rate of per oral mecillinam treatment failure in community-acquired urinary tract infections caused by ESBL-producing escherichia coli
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
High referral rates to secondary care by general practitioners in Norway are associated with GPs' gender and specialist qualifications in family medicine, a study of 4350 consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Referral rates of general practitioners (GPs) are an important determinant of secondary care utilization. The variation in these rates across GPs is considerable, and cannot be explained by patient morbidity alone. The main objective of this study was to assess the GPs’ referral rate to secondary care in Norway, any associations between the referral decision and patient, GP, health care characteristics ... -
High sensitivity C-reactive protein : a useful tool in risk assessment of patients with abdominal obesity?
(Master thesis; Mastergradsoppgave, 2012-06-05)Background: Many obese will eventually develop diabetes and cardiovascular disease. The metabolic syndrome is a cluster of risk factor for these diseases, and low-grade inflammation has been linked to all three conditions. Thesis aims: To investigate if high-sensitivity C-reactive protein can be a useful tool in risk assessment for the development of the metabolic syndrome in abdominally obese ... -
High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ... -
High throughput lipolysis-permeation in vitro model employing the mucus-PVPA barriers to assess drug absorption from lipid-based delivery systems
(Mastergradsoppgave; Master thesis, 2020-05-14)In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...
