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Role of Mannose-Binding Lectin and Complement Activation in Venous Thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2019-12-17)The complement and coagulation systems are two interrelated plasma protein cascades. Evidence from observational and animal studies has proposed a role for the complement system in the development of venous thromboembolism (VTE), but the exact mechanisms remain obscure. The aim of this thesis was to investigate whether activation of the complement system impacts the risk of VTE and to investigate ... -
The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor suppressors pRb and p53, and for protein phosphatase 2A, respectively. At present, 13 different human polyomaviruses are known, and for some of them ... -
Role of microRNAs in venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-09)MicroRNAs (miRNAs) are non-coding RNAs that execute their function by targeted downregulation of gene expressions. There is growing evidence from epidemiological studies and animal models suggesting that the expression level of miRNAs is dysregulated in venous thromboembolism (VTE). In this review, we summarize the current knowledge on the role of miRNAs as biomarkers for VTE and provide general ... -
The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-08)Redox signalling in mitochondria plays an important role in myocardial ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen species (ROS/RNS) modify cellular structures and functions by means of covalent changes in proteins including among others S‐nitros(yl)ation by nitric oxide (NO) and its derivatives, and S‐sulphydration by hydrogen sulphide (H<sub>2</sub>S). ... -
The role of MMP-2 and MMP-14 in cell migration and invasion
(Master thesis; Mastergradsoppgave, 2014-02-03)Cancer is becoming a global epidemic in recent times and can affect different organs in the body and even more worrying is that they do not have a common cause. Several factors have been implicated in the onset and spread of cancers, one of which are the metalloproteinases (MMPs). The MMPs utilize the same strategy they employ in normal physiological processes in pathology, thus creating a dilemma ... -
The role of moderating variables on BOLD fMRI response during semantic verbal fluency and finger tapping in active and educated healthy seniors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)Semantic verbal fluency is among the most employed tasks in cognitive aging research and substantial work is devoted to understanding the underlying mechanisms behind age-related differences at the neural and behavioral levels. The present investigation aimed to evaluate the role of moderating variables, such as age, sex, MMSE, and proxies of cognitive reserve (CR) on the hemodynamic response evoked ... -
Role of monocyte procoagulant functions in the pathophysiology of arterial and venous thrombosis
(Doctoral thesis; Doktorgradsavhandling, 2011-12-16)Monocytter, en klasse hvite blodlegemer i blodet, spiller en sentral rolle i kroppens immunforsvar og for blodets evne til å levre seg og danne en blodpropp. De kan ved stimulering, som ved sykelige tilstander, uttrykke vevsfaktor (TF) på celleoverflaten. TF er ansvarlig for å sette i gang blodproppmekanismen. En blodpropp kan dannes i kroppens samleårer (vener – kalles da dyp venøs trombose eller ... -
The role of NADPH oxidases in diabetic cardiomyopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte ... -
The Role of Need for Cognition in the Association Between Work Demands and Home Outcomes
(Master thesis; Mastergradsoppgave, 2023-04-28)Kjærlighetsrelasjoner er en viktig del av våres liv og forskning viser til at kontekstuelle utfordringer (f.eks., arbeidsmengde), kan negativt påvirke slike relasjoner–et eksempel på jobb–til–liv konflikt. Arbeidet man utfører blir stadig mer komplekst og ansatte må utføre oppgaver som er både ukjente og utfordrende. Selv om slik kvalitativ arbeidsmengde er utbredt blant ansatte, vet vi lite om ... -
The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15) -
Role of Oestrogen α Receptors in Sociosexual Behaviour in Female Rats Housed in a Seminatural Environment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-28)The present study investigated the role of oestrogen receptor (ER)α in the ventromedial nucleus of the hypothalamus (VMN), the preoptic area (POA), the medial amygdala (MePD) and the bed nucleus of stria terminalis (BNST) in sociosexual behaviour in female rats. This was conducted in two sets of experiments, with the VMN and POA investigated in the first set, and the MePD and BNST in the second set. ... -
The role of ovarian reserve markers in fertility and fertility treatment
(Doctoral thesis; Doktorgradsavhandling, 2021-05-14)Ovarian reserve is a key component influencing reproductive function and fertility. Serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are established quantitative markers of ovarian reserve. The overall aim of this thesis comprising four work packages was to study the role of AMH and AFC on different aspects of fertility and fertility treatment. Their specific objectives were: 1) To ... -
The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
The Role of Plasma Extracellular Vesicles and Procoagulant Phospholipid Activity in Venous Thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2021-11-05)Venous thromboembolism (VTE) is the formation of a blood clot in, most commonly, the deep veins of the lower extremities and the pulmonary circulation. VTE is a prevalent disease associated with severe short- and long-term complications. Negatively charged procoagulant phospholipids (PPL), and phosphatidylserine (PS) in particular, are vital to efficient coagulation activation, and found expressed ... -
The Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Background and purpose Preoperative infammatory markers, such as Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio, were shown to be associated with prognosis in patients undergoing pancreatectomy for cancer. However, little is known about their predictive role in a Western population.<p> <p>Methods The Norwegian National Registry for Gastrointestinal ... -
The role of psychosocial factors and treatment need in dental service use and oral health among adults in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-11)<i>Objectives</i> - This study aimed to explore whether population characteristics were associated with the use of dental services, individual's personal oral health practices, dental caries and oral health‐related impacts using the revised Andersen's behavioural model as the theoretical framework.<br><br> <i>Methods</i> - This cross‐sectional study included participants from a Norwegian general ... -
Role of respondents' education as a mediator and moderator in the association between childhood socio-economic status and later health and wellbeing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18) -
A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the ... -
The role of Staphylococcus aureus in allergic disease and cross-reactivity in fish allergy
(Doctoral thesis; Doktorgradsavhandling, 2017-09-29)Aims: The aims was to describe prevalence`s of allergic disease in adolescents and study associations between allergic diseases and Staphylococcus aureus. Secondly, to study cross-reactivity in fish allergic children and the utility of existing and novel tests for fish allergy. Material and Methods: Prevalence of allergic diseases and associations to Staphylococcus aureus was studied in a cross-sectional ... -
The role of steroid hormone receptors in prostate cancer. A study of estrogen- and progesterone receptors in adenocarcinoma of the prostate
(Doctoral thesis; Doktorgradsavhandling, 2018-06-15)Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue ...
