Blar i forfatter Det helsevitenskapelige fakultet "Haapsamo, Mervi"

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    • Nifedipine disturbs fetal cardiac function during hypoxemia in a chronic sheep model at near term gestation 

      Alanne, Leena; Bhide, Amarnath Govind; Lantto, Juulia; Huhta, Heikki; Kokki, Merja; Haapsamo, Mervi; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11)
      Background: Nifedipine is a widely used drug in pregnancies complicated by maternal hypertensive disorders that can be associated with placental insufficiency and fetal hypoxemia. The evidence regarding fetal myocardial responses to nifedipine in hypoxemia is limited.<p> <p>Objective: We hypothesized that nifedipine would not impair fetal sheep cardiac function under hypoxemic environment. In ...

    • Peripheral chemoreflex activation and cardiac function during hypoxemia in near-term fetal sheep without placental compromise 

      Lantto, Juulia; Erkinaro, Tiina; Haapsamo, Mervi; Huhta, Heikki; Alanne, Leena; Kokki, Merja; Ohtonen, Pasi; Bhide, Amarnath; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)
      A drop in arterial oxygen content activates fetal chemoreflex including an increase in sympathetic activity leading to peripheral vasoconstriction and redistribution of blood flow to protect the brain, myocardium, and adrenal glands. By using a chronically instrumented fetal sheep model with intact placental circulation at near-term gestation, we investigated the relationship between peripheral ...