Blar i forfatter Det helsevitenskapelige fakultet "Lassen, Kristoffer"

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    • Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

    • Benchmarking of aggregated length of stay after open and laparoscopic surgery for cancers of the digestive system 

      Lassen, Kristoffer; Nymo, Linn Såve; Olsen, Frank; Søreide, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-23)
      <i>Background</i>: Length of hospital stay (LOS) may serve as a surrogate measure of healthcare quality and resource use, particularly when transfers of care and readmissions are accounted for. This study aimed to benchmark true hospital stay by measuring index, transfer and readmission stays across the range of digestive cancer surgery.<p> <p><i>Methods</i>: A cohort study of all patients ...

    • Centralizing a national pancreatoduodenectomy service: striking the right balance 

      Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne; Labori, Knut Jørgen; Mortensen, Kim Erlend; Søreide, Kjetil; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-07)
      <i>Background</i> - Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus on the optimal balance has not yet been reached. This observational study presents a volume–outcome analysis of a complete national cohort in a health system with ...

    • Functional recovery is considered the most important target: a survey of dedicated professionals 

      Aahlin, Eirik Kjus; von Meyenfeldt, Maarten; Dejong, Cornelis H.C.; Ljungqvist, Olle; Fearon, Kenneth C.; Lobo, Dileep N; Revhaug, Arthur; Wigmore, Stephen J; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases 

      Kryeziu, Kushtrim; Moosavi, Seyed Hossein; Bergsland, Christian Holst; Guren, Marianne; Eide, Peter Andreas Wold; Totland, Max; Lassen, Kristoffer; Abildgaard, Andreas; Nesbakken, Arild; Sveen, Anita; Lothe, Ragnhild Adelheid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and ofer an opportunity to evaluate novel treatment strategies in a personalized fashion. Here we have evaluated spatio-temporal functional and molecular dynamics of fve PDO models ...

    • Major postoperative complications are associated with impaired long-term survival after gastro-esophageal and pancreatic cancer surgery: a complete national cohort study 

      Aahlin, Eirik Kjus; Olsen, Frank; Uleberg, Bård; Jacobsen, Bjarne K.; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-18)
      Background: Some studies have reported an association between complications and impaired long-term survival after cancer surgery. We aimed to investigate how major complications are associated with overall survival after gastro-esophageal and pancreatic cancer surgery in a complete national cohort. <br> Methods: All esophageal-, gastric- and pancreatic resections performed for cancer in Norway ...

    • Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers 

      Takala, Sini; Lassen, Kristoffer; Søreide, Kjetil; Sparrelid, Ernesto; Angelsen, Jon-Helge; Bringeland, Erling Audun; Eilard, Malin S.; Hemmingsson, Oskar; Isaksson, Bengt; Karjula, Heikki; Lammi, Jukka-Pekka; Larsen, Peter N.; Lavonius, Maija; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Nordin, Arno; Pless, Torsten; Sandström, Per; Sandvik, Oddvar Mathias; Vaalavuo, Yrjö; Villard, Christina; Sallinen, Ville (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-28)
      Background and objective: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies. Methods: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals ...

    • Preoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Study 

      Sahakyan, Mushegh; Brudvik, Kristoffer Watten; Angelsen, Jon-Helge; Dille-Amdam, Rachel G.; Sandvik, Oddvar Mathias; Edwin, Bjørn von Gohren; Nymo, Linn Såve; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)
      Background Preoperative inflammatory markers were shown to be associated with prognosis following surgery for hepato-pancreato-biliary cancer. Yet little evidence exists about their role in patients with colorectal liver metastases (CRLM). This study aimed to examine the association between selected preoperative inflammatory markers and outcomes of liver resection for CRLM.<p> <p>Methods Data ...

    • Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma 

      Sahakyan, Mushegh A.; Verbeke, Caroline S.; Tholfsen, Tore; Ignjatovic, Dejan; Kleive, Dyre; Buanes, Trond; Lassen, Kristoffer; Røsok, Bård I.; Labori, Knut Jørgen; Edwin, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-22)
      Background. Resection margin status is considered one of the few surgeon-controlled parameters affecting prognosis in pancreatic ductal adenocarcinoma (PDAC). While studies mostly focus on resection margins in pancreatoduodenectomy, little is known about their role in distal pancreatectomy (DP). This study aimed to investigate resection margins in DP for PDAC.<p> <p>Methods. Patients who ...

    • Risk factors, complications and survival after upper abdominal surgery: A prospective cohort study 

      Aahlin, Eirik Kjus; Tranø, Geir; Johns, Neil; Horn, Arild; Søreide, Jon Arne; Fearon, Kenneth Christopher H.; Revhaug, Arthur; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-07)
      <p>Background: Preoperative weight loss and abnormal serum-albumin have traditionally been associated with reduced survival. More recently, a correlation between postoperative complications and reduced long-term survival has been reported and the significance of the relative proportion of skeletal muscle, visceral and subcutaneous adipose tissue has been examined with conflicting results. We ...

    • The Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Study 

      Sahakyan, Mushegh; Kleive, Dyre; Dille-Amdam, Rachel G.; Kjeseth, Trond; Waardal, Kim; Edwin, Bjørn von Gohren; Nymo, Linn Såve; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)
      Background and purpose Preoperative infammatory markers, such as Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio, were shown to be associated with prognosis in patients undergoing pancreatectomy for cancer. However, little is known about their predictive role in a Western population.<p> <p>Methods The Norwegian National Registry for Gastrointestinal ...

    • Short-term outcomes after elective colon cancer surgery: an observational study from the Norwegian registry for gastrointestinal and HPB surgery, NoRGast 

      Nymo, Linn Såve; Norderval, Stig; Eriksen, Morten Tandberg; Wasmuth, Hans; Kørner, Hartwig; Bjørnbeth, Bjørn Atle; Moger, Thomas; Viste, Asgaut; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)
      BACKGROUND: To describe the real burden of major complications after elective surgery for colon cancer in Norway, and to assess which predictors that are significantly associated with the short-term outcome. <br> <br> METHODS: An observational, multi-centre analysis of prospectively registered colon resections registered into the Norwegian Registry for Gastrointestinal Surgery, NoRGast, between ...

    • Translation and validation of the Norwegian version of the postoperative quality of recovery score QoR-15 

      Bergestuen, Linda; Moger, Thomas A. Waksvik; Oterhals, Kjersti; Pfeffer, Frank; Nestvold, Torunn Kristin; Norderval, Stig; Nymo, Linn Såve; Havnes, Kjerstin; Lassen, Kristoffer; Breivik, Kyrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-08)
      Background As patient-centered care gains more attention, assessing the patient's perspective on their recovery has become increasingly important. In response to the need for a reliable and valid patient reported outcome measurement tool for major surgical resections in Norway. The Norwegian Registry for Gastrointestinal Surgery (NORGAST) initiated a project to translate and evaluate QoR-15's ...

    • Treatment and survival of patients with pancreatic ductal adenocarcinoma: 15-year national cohort 

      Nymo, Linn Såve; Lassen, Kristoffer; Myklebust, Tor Åge; Møller, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-08)
      Background - Improvement in survival from pancreatic ductal adenocarcinoma (PDAC) has been reported in trial settings but is less explored in unselected cohorts. The aim of this study was to assess trends in provision of treatments and survival in Norway over a 15-year period following the implementation of hepato-pancreato-biliary (HPB) multidisciplinary teams, centralization of surgery, and ...

    • Variation in use of open and laparoscopic distal pancreatectomy and associated outcome metrics in a universal health care system 

      Søreide, Kjetil; Nymo, Linn Såve; Kleive, Dyre; Olsen, Frank; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-01)
      <i>Background</i> - Universal health care (UHC) should ensure equal access to and use of surgery, but few studies have explored variation in UHC systems. The objective was to describe practice of distal pancreatectomy in Norway covered exclusively by an UHC.<p><p> <i>Methods</i> - Data on all patients undergoing distal pancreatectomy from the Norwegian Patient Register over a 5-year period. ...

    • Weight loss and BMI criteria in GLIM's definition of malnutrition is associated with postoperative complications following abdominal resections – Results from a National Quality Registry 

      Skeie, Eli; Tangvik, Randi Julie; Nymo, Linn Såve; Harthug, Stig; Lassen, Kristoffer; Viste, Asgaut (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-20)
      <i>Background & aims</i> - Although malnutrition is thought to be common among patients with intraabdominal diseases and is recognized as a risk factor for postoperative complications, diagnostic criteria for malnutrition have not been consistent. Thus, the Global Leadership Initiative in Malnutrition (GLIM) has recently published new criteria for malnutrition. The aims of this study were to investigate ...