• Are Patient Views about Antibiotics Related to Clinician Perceptions, Management and Outcome? A Multi-Country Study in Outpatients with Acute Cough 

      Coenen, Samuel; Francis, Nick; Kelly, Mark; Hood, Kerenza; Nuttal, Jacqui; Little, Paul; Verheij, Theo J. M.; Melbye, Hasse; Goossens, Herman; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Outpatients with acute cough who expect, hope for or ask for antibiotics may be more unwell, benefit more from antibiotic treatment, and be more satisfied with care when they are prescribed antibiotics. Clinicians may not accurately identify those patients. Objective: To explore whether patient views (expecting, hoping for or asking for antibiotics) are associated with illness presentation ...
    • Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial 

      Gillespie, David; Butler, Christopher C.; Bates, Janine; Hood, Kerenza; Melbye, Hasse; Phillips, Rhiannon; Stanton, Helen; Alam, Mohammed Fasihul; Cals, Jochen; Cochrane, Ann; Kirby, Nigel; Llor, Carl; Lowe, Rachel; Naik, Gurudutt; Riga, Evgenia; Sewell, Bernadette; Thomas-Jones, Emma; White, Patrick; Francis, Nick (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)
      <i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ...
    • Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD 

      Gillespie, David; Francis, Nick; Ahmed, Haroon; Hood, Kerenza; Llor, Carl; White, Patrick; Thomas-Jones, Emma; Stanton, Helen; Sewell, Bernadette; Phillips, Rhiannon; Naik, Gurudutt; Melbye, Hasse; Lowe, Rachel; Kirby, Nigel; Cochrane, Ann; Bates, Janine; Alam, Mohammed Fasihul; Butler, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)
      Background: It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.<p> <p>Aim: To investigate the factors associated with post-consultation COPD health status in patients presenting with AECOPD in this sett ...
    • C-reactive protein point-of-care testing for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease: The PACE RCT 

      Francis, Nick; Gillespie, David; White, Patrick; Bates, Janine; Lowe, Rachel; Sewell, Bernadette; Phillips, Rhiannon; Stanton, Helen; Kirby, Nigel; Wootton, Mandy; Thomas-Jones, Emma; Hood, Kerenza; Llor, Carl; Cals, Jochen; Melbye, Hasse; Naik, Gurudutt; Gal, Micaela; Fitzsimmons, DF; Alam, Mohammed Fasihul; Riga, Evgenia; Cochrane, Ann; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03)
      Background - Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed antibiotics, but these may not be beneficial, and they can cause side effects and increase the risk of subsequent resistant infections. Point-of-care tests (POCTs) could safely reduce inappropriate antibiotic prescribing and antimicrobial resistance.<p> ...
    • C-reactive protein-guided antibiotic prescribing for COPD exacerbations: A qualitative evaluation 

      Phillips, Rhiannon; Stanton, H.; Singh-Mehta, A.; Gillespie, David; Bates, Janine; Gal, Micaela; Thomas-Jones, Emma; Lowe, Rachel; Hood, Kerenza; Llor, Carl; Melbye, Hasse; Cals, Jochen; White, Patrick; Butler, Christopher C.; Francis, Nick (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
      Background - Antibiotics are prescribed to >70% of patients presenting in primary care with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The PACE randomised controlled trial found that a C-reactive protein point-of-care test (CRP-POCT) management strategy for AECOPD in primary care resulted in a 20% reduction in patient-reported antibiotic consumption over 4 weeks.<p> <p>Aim ...
    • The complexity of managing COPD exacerbations: a grounded theory study of European general practice 

      Risør, Mette Bech; Spigt, Mark; Iversen, Robert; Godycki-Cwirko, Maciek; Francis, Nick; Altiner, Attila; Andreeva, Elena; Kung, Kenny; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      To understand the concerns and challenges faced by general practitioners (GPs) and respiratory physicians about primary care management of acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). 21 focus group discussions (FGDs) were performed in seven countries with a Grounded Theory approach. Each country performed three rounds of FGDs. Primary and secondary care in ...
    • How do general practitioners implement decision-making regarding COPD patients with exacerbations? An international focus group study 

      Laue, Johanna; Melbye, Hasse; Halvorsen, Peder Andreas; Andreeva, Elena; Godycki-Cwirko, Maciek; Wollny, Anja; Francis, Nick; Spigt, Mark; Kung, Kenny; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-08)
      <b>Purpose:</b> To explore the decision-making of general practitioners (GPs) concerning treatment with antibiotics and/or oral corticosteroids and hospitalization for COPD patients with exacerbations.<br> <b>Methods:</b> Thematic analysis of seven focus groups with 53 GPs from urban and rural areas in Norway, Germany, Wales, Poland, Russia, the Netherlands, and Hong Kong.<br> <b>Results:</b> ...
    • International perception of lung sounds: a comparison of classification across some European borders 

      Aviles Solis, Juan Carlos; Vanbelle, Sophie; Halvorsen, Peder Andreas; Francis, Nick; Cals, Jochem W L; Andreeva, Elena A; Marques, Alda; Piirila, Paivi; Pasterkamp, Hans; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-18)
      Introduction: Lung auscultation is helpful in the diagnosis of lung and heart diseases; however, the diagnostic value of lung sounds may be questioned due to interobserver variation. This situation may also impair clinical research in this area to generate evidence-based knowledge about the role that chest auscultation has in a modern clinical setting. The recording and visual display of lung sounds ...
    • Why do physicians lack engagement with smoking cessation treatment in their COPD patients? A multinational qualitative study 

      Van Eerd, Eva A.M.; Risør, Mette Bech; Spigt, Marcus; Godycki-Ćwirko, Maciek; Andreeva, Elena; Francis, Nick; Wollny, Anja; Melbye, Hasse; van Schayck, Onno; Kotz, Daniel (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-23)
      Smoking cessation is the only effective intervention to slow down the accelerated decline in lung function in smokers with chronic obstructive pulmonary disease. Nevertheless, physicians often do not routinely provide evidence-based smoking cessation treatment to their patients. To understand underlying reasons, we explored how physicians engage in smoking cessation treatment in their chronic ...