Blar i forfatter Det helsevitenskapelige fakultet "Wold, Ragnhild Margrete"
-
Hypothermia-induced myocardial calcium overload –a study of intracellular Ca2+ handling during profound hypothermia and rewarming
Wold, Ragnhild Margrete (Doctoral thesis; Doktorgradsavhandling, 2016-09-30)We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ...