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Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression. Here, we investigated the dynamics of tissue resident macrophages in the induction and expansion of salivary gland TLS. We induced Sjögren’s disease by ... -
Exploring views among Norwegian Sámi regarding gambling and gambling treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-19)Aim: To explore gambling in the indigenous Sámi culture by studying thoughts, ideas and attitudes towards gambling among Sámi and people living in majority Sámi areas with knowledge of the culture. <p> <p>Methods: The topic was investigated in an inductive thematic analysis of semi-structured interviews with 14 people (n = 13 self-reported Sámi ethnicity). <p> <p>Results: The majority of the ... -
Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11)Background - Nutri-Score is a scientifically validated 5-color front-of-pack nutrition label reflecting the nutrient profile of foods. It has been implemented in several European countries on a voluntary basis, pending the revision of the European labeling regulation. Hence, scientific evidence is needed regarding the ability of the nutrient profile underlying the Nutri-Score (uNS-NPS, 2023-updated ... -
Theoretical Underpinnings of the Political Priorities of Municipal Healthcare Services in Norway. How a Rawlsian Heuristic Can Aid Political Decision-Making in Municipal Healthcare Services
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-11)This paper aims to discuss the current criteria for municipal priorities in municipal healthcare services in Norway in light of major theories from political philosophy on social justice, such as John Rawlsʼs theory of justice and utilitarianism. Our first goal is to show that perspectives from political philosophy could prove useful for increasing our understanding of the current priority-setting ... -
Tildelingsfunksjonens rolle i prioritering av kommunale tjenester
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-11)Bakgrunn: Den demografiske utviklingen, med økt antall og andel eldre, krever strengere prioritering av ressurser innenfor kommunale helse- og omsorgstjenester. Tildelingsfunksjonen har en viktig rolle i prioriteringen av tjenester på faglig nivå. Med utgangspunkt i teori om styringsmodeller i offentlig sektor belyser studien forskningsspørsmålet: Innenfor hvilke organisatoriske rammer skjer ... -
Virtually isolated: social identity threat predicts social approach motivation via sense of belonging in computer-supported collaborative learning
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-13)Collaboration improves multiple academic and social outcomes. Accordingly, computer-supported collaborative learning (CSCL) can be beneficial in distance education contexts to overcome the issues specific to online learning (e.g., underperformance, low identification with university). Distance universities often attract a substantial number of non-traditional students (e.g., students with disability, ... -
Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-20)Introduction - Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD). The aim of the present study was to examine the development of mental distress and quality of life (QoL) among AUD patients in treatment who did or ... -
Artificial Intelligence Algorithm for Subclinical Breast Cancer Detection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-03)Importance - Early breast cancer detection is associated with lower morbidity and mortality.<p> <p>Objective - To examine whether a commercial artificial intelligence (AI) algorithm for breast cancer detection could estimate the development of future cancer.<p> <p>Design, Setting, and Participants - This retrospective cohort study of 116 495 women aged 50 to 69 years with no prior history of ... -
Genetics of hip dysplasia - a systematic literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-01)Background - Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2–3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 years of age. We aim to explore the genetic background of DDH in order to improve diagnosis and personalize treatment.<p> <p>Methods - We conducted a structured literature ... -
Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-01)Isogenic bacterial cell populations are phenotypically heterogenous and may include subpopulations of antibiotic tolerant or heteroresistant cells. The reversibility of these phenotypes and lack of biomarkers to differentiate functionally different, but morphologically identical cells is a challenge for research and clinical detection. To overcome this, we present ´Cellular Phenotypic Profiling and ... -
How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-05)Many epidemiological studies use a single blood sample per participant to assess exposure, but it is unclear how well a single sample represents longer term exposure. We performed a simulation study using summary statistics for repeated serum PFOA measurements from several previous studies in men to generate plausible serum concentrations over time, taking within-subject correlations into account. ... -
Effect of pharmacological treatment of attention-deficit/hyperactivity disorder on later psychiatric comorbidity: a population-based prospective long-term study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-19)Background Psychiatric comorbidity is frequent among persons with attention-deficit/hyperactivity disorder (ADHD). Whether pharmacological treatment of ADHD influences the incidence of psychiatric comorbidity is uncertain.<p> <p>Objective To investigate associations and causal relations between pharmacological treatment of ADHD and incidence of subsequent comorbid psychiatric diagnoses. <p>Methods ... -
Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-11)Background - After 3 months of anticoagulation for venous thromboembolism (VTE), the decision needs to be made whether to stop anticoagulation or extend treatment indefinitely. The VTE-PREDICT calculator can be used to estimate individual risks of VTE recurrence and bleeding to guide this decision.<p> <p>Objectives - To evaluate the impact of predicted individual risks of recurrence and bleeding ... -
Roles of miR-20a-5p in breast cancer based on the clinical and multi-omic (CAMO) cohort and in vitro studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-23)MicroRNAs are involved in breast cancer development and progression, holding potential as biomarkers and therapeutic targets or tools. The roles of miR-20a-5p, a member of the oncogenic miR-17-92 cluster, remain poorly understood in the context of breast cancer. In this study, we elucidate the role of miR-20a-5p in breast cancer by examining its associations with breast cancer risk factors and ... -
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-02)Background - While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) and bipolar (BD) spectrum disorders. There is however, limited knowledge about the longitudinal course of this relationship.<p> <p>Methods - Systemic inflammation (C-Reactive Protein, CRP) ... -
The Tumor Immune Microenvironment as a Regulator of Oral Cancer Progression
(Doctoral thesis; Doktorgradsavhandling, 2024-12-05)Oral squamous cell carcinoma (OSCC) is a growing global health concern, particularly among the younger population. The immune system plays an important role in tumor progression and a high density of tumor infiltrating T lymphocytes is linked to improved patient prognosis and therapy response. Tumor-associated high endothelial venules (TA-HEVs) facilitate lymphocyte entry into tumors via the ... -
ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-22)Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is targeted through modifications of its glycan structures. We show that ADA2 interacts with DNA molecules, altering their sequences by converting deoxyadenosine (dA) to deoxyinosine (dI). We ... -
Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)Appetite loss is prevalent in patients with advanced cancer and negatively affects their quality of life. However, understanding of the factors associated with appetite loss is limited. The current study aims to explore characteristics and therapeutic interventions used for patients with and without appetite loss admitted to an acute palliative care unit. Patient characteristics and patientreported ... -
Exploring the barriers to diagnosing malnutrition in patients with cancer: A study on oncologists' perspectives
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-05)Background and aim: Patients with cancer are at high risk of malnutrition, yet relevant ICD-10 codes for malnutrition are underutilized in cancer clinics. Understanding oncologists' perspectives is crucial for optimizing malnutrition diagnosis codes and enhancing nutritional practices to improve patient care. This study aims to explore oncologists' perspectives on the use and feasibility of the ... -
Medication Self-Management for Home Care Users Receiving Multidose Drug Dispensing: Qualitative Interview Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-22)Background: Multidose drug dispensing (MDD) is an adherence aid where medicines are machine-dispensed in disposable unit bags, usually for a 14-day period. MDD replaces manually filled dosettes in many home care services in Norway. While evidence suggests that MDD can improve medication adherence and reduce errors, there are few studies on how patients manage MDD at home and how this affects their ...