The inflammatory repressor TNIP1/ABIN-1 is important for keeping in check inflammatory and cell-death pathways to avoid potentially dangerous sustained activation of these pathways. We have now found that TNIP1 is rapidly degraded by selective macroautophagy/autophagy early (0–4 h) after activation of TLR3 by poly(I:C)-treatment to allow expression of pro-inflammatory genes and proteins. A few hours ...

In the times of pandemic, we experienced problems with supply bottlenecks for the solvents normally used for extraction and analysis of persistent organic pollutants (POPs; i.e. PCBs, PBDEs and organochlorine pesticides) in our laboratory and, considered to start using solvents from another producer alternatively. Since we analyze POPs at very low concentration levels and other consumables are ...

Introduction: Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder that affects multiple organs. In this study, we investigated symptoms of pain and presence of small and large fiber neuropathy in the juvenile and adult form of DM1.<p> <p>Method: Twenty genetically verified DM1 patients were included. Pain was assessed, and neurological examination and investigations of ...

Study Design - Prospective pharmacoepidemiologic study.<p> <p>Objective - To investigate clinical and sociodemographic factors associated with persistent opioid use in the years following spine surgery among patients with persistent opioid use preceding lumbar spine surgery.<p> <p>Summary of Background Data - It is unknown whether successful spine surgery leads to a cessation of preoperative ...

The age of the onset of menstruation, termed menarche, has been declining for decades worldwide. Approximately 12% of Australian girls reach menarche between eight to 11 years of age. Current health and physical education subject guidelines from the Australian Curriculum Assessment and Reporting Authority state that puberty education should be introduced to students between year levels five to six ...

Vaccine hesitancy has been described as any delay or refusal of vaccines despite their availability and is increasing in Australia and other middle to high-income countries. The aim of this study is to gain a deep understanding of the experiences and influences on vaccine hesitant children and their families. A qualitative interview approach was undertaken with vaccine hesitant parents and pregnant ...

The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, ...

Abstrakt Tittel: Jordmødres bruk av fødestillinger i forløsning av barnet og sammenhengen med egen preferanse, kvinners brukermedvirkning og rammefaktorer relatert til klinisk praksis. Hensikt: Hensikten med studien er gjennom å kartlegge selvrapporterte fødestillinger jordmor har brukt siste året, å undersøke hvilke faktorer som påvirker bruk av fødestilling.   Metode: Tverrsnittstudi ...

Hensikt: Å utforske norske jordmødres erfaringer i møte med innvandrerkvinner i fødsel som ikke behersker det norske språk. Metode: Kvalitativ metode med åtte individuelle intervju. I dette studiet ble det brukt en hermeneutisk tilnærming og data ble analysert etter livsverden hermeneutikk. Funn: Funnene presenteres gjennom fem temaer: språkbarrierer kan gi disharmoni og hindre deltakelse, ...

Background and objectives: Chronic headaches are a frequent cause of pain and disability. The purpose of this randomized trial was to examine whether transcranial direct current stimulation (tDCS) applied to the primary motor cortex, reduces pain and increases daily function in individuals suffering from primary chronic headache.<p> <p>Materials and methods: A prospective, randomized, controlled ...