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    • Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders 

      Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-17)
      <p><i>Background - </i>Although several studies have found reduced plasma BDNF levels in patients with severe mental disorders, the sample sizes have been small and have exhibited variation and heterogeneity. Furthermore, long-term neurobiological changes following childhood trauma and clinical severity have been linked to a reduction in BDNF levels. Accordingly, we aim to clarify, using the largest ...