Blar i forfatter Doktorgradsavhandlinger (Helsefak) "Jarhelle, Elisabeth"
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What are the molecular consequences of germline mutations in breast and ovarian cancer susceptibility genes in a Norwegian breast and ovarian cancer population?
Jarhelle, Elisabeth (Doctoral thesis; Doktorgradsavhandling, 2018-06-01)It is estimated that 5-10% of breast cancers (BC) and 25% of ovarian cancers (OC) are caused by inherited sequence variants in genes. In the mid 90’s, the two genes BRCA1 and BRCA2 were discovered to be directly associated with increased risk of BC and OC. Molecular screening of these two genes has revealed several disease causing variants as well as variants of unknown clinical significance (VUS). ...