<i>Staphylococcus aureus</i> and <i>Enterococcus faecium</i> are opportunistic pathogens that may cause diseases ranging from minor skin infection to severe blood stream infections. The emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant enterococcal strains severely limits treatment options. Bacteria release extracellular vesicles (EVs), defined as ...