Browsing Doktorgradsavhandlinger (Helsefak) by Author "Norreen-Thorsen, Marthe"
-
The identification of cell type defining genes across human tissues and the functional study of the endothelial adhesion G protein-coupled receptor L4
Norreen-Thorsen, Marthe (Doctoral thesis; Doktorgradsavhandling, 2023-06-30)Cell type specific gene expression profiles underlie differences in cell morphology, behaviour, and specialized function. Single cell RNA sequencing can be used to measure gene expression in individual cells, but challenges remain including limited read-depth, artefactual changes due to dissociation from tissue, difficulties in the analysis of fragile or morphologically complex cell types, and bias ...