Blar i forfatter Doktorgradsavhandlinger (Helsefak) "Thiyagarajan, Dhivya"
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Progressive lupus nephritis : biological consequences of renal DNaseI gene silencing
Thiyagarajan, Dhivya (Doctoral thesis; Doktorgradsavhandling, 2013-10-11)Systemic lupus erythematous (SLE) is an autoimmune syndrome which occurs most often between the ages 10-50 years. Lupus nephritis is the most severe clinical manifestation of SLE. 30-60% of the SLE patients may develop lupus nephritis during lifetime. At a certain time point in the life of (NZBxNZW) F1 mice prone to develop lupus nephritis, the expression of renal DNaseI endonuclease is lost. This ...