Blar i forfatter Artikler, rapporter og annet (UB) "Aachmann, Finn Lillelund"

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    • Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin 

      Felipe Guerrero-Garzón, Jaime; Madland, Eva; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn Lillelund; Courtade, Gaston; Urban, Ernst; Rückert, Christian; Busche, Tobias; Kalinowski, Jörn; Cao, Yan-Ru; Jiang, Yi; Jiang, Cheng-lin; Selivanova, Galina; Zotchev, Sergey (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-10)
      Heterologous expression of a biosynthesis gene cluster from <i>Amycolatopsis</i> sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investigation revealed, that pre-treatment of cancer cells with a mixture of felipeptins resulted in ...