Blar i forfatter Artikler, rapporter og annet (UB) "Dahl, Tuva Børresdatter"

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    • Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology 

      Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland; Michelsen, Annika Elisabet; Ranheim, Trine; Nezvalova-Henriksen, Katerina; Dyrhol-Riise, Anne Ma; Holme, Pål Andre; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Ahlen, Maria Therese; Aukrust, Pål; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-28)
      Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are scarce. We assessed the presence of anti-PF4/polyanion antibodies in prospectively collected serum from an unselected cohort ...

    • Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity 

      Søraas, Arne Vasli; Grødeland, Gunnveig; Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Fevang, Børre; Murphy, Sarah Louise Mikalsen; Huse, Camilla; Nygaard, Anders Benteson; Steffensen, Anne Katrine; Al-Baldawi, Huda; Holberg-Petersen, Mona; Andresen, Lise Lima; Ågnes, Camilla; Ranheim, Trine; Schanke, Ylva; Istre, Mette Stausland; Dahl, John Arne; Chopra, Adity; Dudman, Susanne; Kaarbø, Mari; Andersen, Jan Terje; Vaage, Eline Benno; Tran, Trung The; Vaage, John Torgils; Michelsen, Annika Elisabet; Müller, Fredrik; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Holter, Jan Cato; Lund-Johansen, Fridtjof (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p> <p>Methods: We measured inflammatory mediators, antibodies to the ...

    • Coagulopathy and adverse outcomes in hospitalized patients with COVID-19: results from the NOR-Solidarity trial 

      Ueland, Thor; Michelsen, Annika Elisabet; Tveita, Anders; Kåsine, Trine; Dahl, Tuva Børresdatter; Finbråten, Ane-Kristine; Holten, Aleksander Rygh; Skjønsberg, Ole Henning; Mathiessen, Alexander; Nezvalova-Henriksen, Katerina; Trøseid, Marius; Aaløkken, Trond Mogens; Halvorsen, Bente; Dyrhol-Riise, Anne Ma; Barratt-Due, Andreas; Aukrust, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-07)
      Background - Several studies have examined parameters of increased thrombogenicity in COVID-19, but studies examining their association with long-term outcome and potential effects of antiviral agents in hospitalized patients with COVID-19 are scarce.<p> <p>Objectives - To evaluate plasma levels of hemostatic proteins during hospitalization in relation to disease severity, treatment modalities, ...

    • Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab 

      Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-17)
      Background - Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab and their correlations with neutrophils, C-reactive protein (CRP), troponin T, MSI and infarct size.<p> <p>Methods - STEMI patients were randomised to receive a single ...

    • Endonuclease v regulates atherosclerosis through c-c motif chemokine ligand 2-mediated monocyte infiltration 

      Kong, Xiang Yi; Huse, Camilla; Yang, Kuan; Øgaard, Jonas; Jimenez, Natalia Berges; Vik, Erik Sebastian; Nawaz, Meh Sameen; Quiles-Jiménez, Ana M T; Abbas, Azhar; Gregersen, Ida; Holm, Sverre; Bjerkli, Vigdis; Rashidi, Azita; Fladeby, Cathrine; Suganthan, Rajikala; Sagen, Ellen Lund; Skjelland, Mona; Lång, Anna; Bøe, Stig Ove; Bjørås, Magnar; Aukrust, Pål; Alseth, Ingrun; Halvorsen, Bente; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      BACKGROUND: In cardiovascular diseases, atherosclerotic disorder are the most frequent and important with respect to morbidity and mortality. Inflammation mediated by immune cells is central in all parts of the atherosclerotic progress, and further understanding of the underlying mechanisms is needed. Growing evidence suggests that deamination of adenosine-toinosine in RNA is crucial for a correct ...

    • Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-16)
      A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates with their gut microbial dysbiosis. The gut microbiota dependent metabolite trimethylamine N-oxide (TMAO) has been linked to several metabolic and inflammatory disorders, but has ...

    • Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia 

      Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Schultz, Nina Haagenrud; Nyman, Tuula Anneli; Fladeby, Cathrine; Seljeflot, Ingebjørg; Ueland, Thor; Stensland, Maria; Mjaaland, Siri; Goll, Guro Løvik; Nissen-Meyer, Lise Sofie Haug; Aukrust, Pål; Skagen, Karolina Ryeng; Gregersen, Ida; Skjelland, Mona; Holme, Pål Andre; Munthe, Ludvig Andre; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      Aims - We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). We aimed to investigate the pathogenic immunological responses operating in these patients.<p> <p>Methods and results - We assessed circulating inflammatory markers ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
      Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.<p> <p>Methods In this exploratory sub-study of the ASSAIL-MI trial, we examined leukocyte differential counts and their relation to myocardial salvage and peak troponin T (TnT) in STEMI ...

    • Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection 

      Lekva, Tove; Ueland, Thor; Halvorsen, Bente; Murphy, Sarah Louise Mikalsen; Dyrhol-Riise, Anne Ma; Tveita, Anders Aune; Finbråten, Ane-Kristine; Mathiessen, Alexander; Muller, Karl Erik; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Lerum, Tøri Vigeland; Aukrust, Pål; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
      Background: The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated senescence markers chitotriosidase, ...

    • Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2 

      Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Søraas, Arne Vasli; Fevang, Børre; Steffensen, Anne Katrine; Al-Baldawi, Huda; Lund-Johansen, Fridtjof; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Dudman, Susanne; Müller, Fredrik; Holter, Jan Cato (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-31)
      The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result of a higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether the Omicron variant generates a higher viral load than that of the Delta variant in saliva and nasopharynx. Both specimens were collected from 52 Omicron and 17 Delta cases at two time points one week ...

    • Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies 

      Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen; Yang, Kuan; Quiles Jimenez, Ana Maria Teresa; Heggelund, Lars; Muller, Karl Erik; Tveita, Anders Aune; Michelsen, Annika Elisabet; Bøe, Simen; Holten, Aleksander Rygh; Hoel, Hedda Benedicte; Mathiessen, Alexander; Aaløkken, Trond Mogens; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Nezvalova-Henriksen, Katerina; Lerum, Tøri Vigeland; Müller, Fredrik; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)
      Background - T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.<p> <p>Objectives - To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.<p> <p>Methods ...