Blar i forfatter Artikler, rapporter og annet (UB) "Jackson, Sophie E."

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    • Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation 

      Přáda Brichtová, Eva; Monika, Krupová; Bouř, Petr; Lindo, Viv; Gomes dos Santos, Ana; Jackson, Sophie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      The physical stability of peptide-based drugs is of great interest to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs of which are frequently used in the treatment of type 2 diabetes. We investigated the physical stability of GLP-1 and its C-terminal amide derivative, GLP-1-Am, both of which aggregate into amyloid fibrils. While off-pathway ...