Blar i forfatter Artikler, rapporter og annet (UB) "Ma, Ying Jie"

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    • Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement 

      Zhang, Jie; Song, Lihong; Pedersen, Dennis V.; Li, Anna; Lambris, John D.; Andersen, Gregers Rom; Mollnes, Tom Eirik; Ma, Ying Jie; Garred, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)
      Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, whether this observation is C3 dependent is unknown. By application of the C3-inhibitor Cp40, we found that ...