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dc.contributor.advisorLejon, Tore
dc.contributor.authorThomassen, Ivar Kristian
dc.date.accessioned2013-07-19T12:41:40Z
dc.date.available2013-07-19T12:41:40Z
dc.date.issued2013-05
dc.description.abstractRecent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific synthesis of β-substituted β-aminoboronates followed by oxidation to the boronic acid and subsequent esterification using an enantiomerically pure carbohydrate in order to increase water solubility and potential activity. The oxidation to the boronic acid and following esterification has not yet been accomplished for the target molecules, but exploratory reactions seem to indicate that it is possible. It was also discovered that for certain benzylic halides ultrasound quite unexpectedly led to dimerisation. The scope and limitations of this discovery was explored.en
dc.identifier.urihttps://hdl.handle.net/10037/5292
dc.identifier.urnURN:NBN:no-uit_munin_5004
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2013 The Author(s)
dc.subject.courseIDKJE-3900en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Organisk kjemi: 441en
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Organic chemistry: 441en
dc.titleSynthesis of β-substituted β-aminoboronatesen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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