English
norskBlar i forfatter Fakultet for naturvitenskap og teknologi "Labriere, Christophe"
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Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-13)By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC ... -
Development of potent cholinesterase inhibitors based on a marine pharmacophore
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)The management of neurological disorders such as dementia associated with Alzheimer's or Parkinson's disease includes the use of cholinesterase inhibitors. These compounds can slow down the progression of these diseases and can also be used in the treatment of glaucoma and myasthenia gravis. The majority of the cholinesterase inhibitors used in the clinic are derived from natural products and our ... -
Heterocyclic cellular lipid peroxidation inhibitors inspired by the marine antioxidant barettin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)The marine environment remains a rich source for the discovery and development of novel bioactive compounds. The present paper describes the design, synthesis and biological evaluation of a library of small molecule heterocyclic mimetics of the marine 2,5-diketopiperazine barettin which is a powerful natural antioxidant. By mainly focusing on the influence from the brominated indole and heterocyclic ... -
Phidianidine A and Synthetic Analogues as Naturally Inspired Marine Antifoulants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)Stationary and slow-moving marine organisms regularly employ a natural product chemical defense to prevent being colonized by marine micro- and macroorganisms. While these natural antifoulants can be structurally diverse, they often display highly conserved chemistries and physicochemical properties, suggesting a natural marine antifouling pharmacophore. In our current report, we investigate the ...
