A major barrier to applying deep segmentation models in the medical domain is their typical data-hungry nature, requiring experts to collect and label large amounts of data for training. As a reaction, prototypical few-shot segmentation (FSS) models have recently gained traction as data-efficient alternatives. Nevertheless, despite the recent progress of these models, they still have some essential ...

A class of DNA folds/structures known collectively as G-quadruplexes (G4) commonly forms in guanine-rich areas of genomes. G4-DNA is thought to have a functional role in the regulation of gene transcription and telomerase-mediated telomere maintenance and, therefore, is a target for drugs. The details of the molecular interactions that cause stacking of the guanine-tetrads are not well-understood, ...

Symmetry assumptions on the geometrical framework have provided successful mechanisms to develop physically meaningful solutions to many problems. In tele-parallel gravity, invariance of the frame and spin-connection under a group of motions defines an affine symmetry group. Here, we assume there exists a three-dimensional group of affine symmetries acting simply transitively on a spatial hypersurface ...

Patient-gathered self-management data and shared decision-making are touted as the answer to improving an individual’s health situation as well as collaboration between patients and their providers leading to more effective treatment plans. However, there is a gap between this ideal and reality – a lack of data-sharing technology. Here, we present the impact that the FullFlow System for sharing ...

Deep learning has the potential to revolutionize medical practice by automating and performing important tasks like detecting and delineating the size and locations of cancers in medical images. However, most deep learning models rely on augmentation techniques that treat medical images as natural images. For contrast-enhanced Computed Tomography (CT) images in particular, the signals producing the ...

The EISCAT (European Incoherent Scatter Scientific Association) Heating facility was used to transmit powerful high-frequency (HF) electromagnetic waves into the Fregion ionosphere to enhance optical emissions at 557.7 and 630.0 nm from atomic oxygen. The emissions were imaged by several stations of ALIS (Auroral Large Imaging System) in northern Sweden, and the EISCAT UHF incoherent scatter radar ...

Bacterial NAD⁺-dependent DNA ligases (LigAs) are enzymes involved in replication, recombination, and DNA-repair processes by catalyzing the formation of phosphodiester bonds in the backbone of DNA. These multidomain proteins exhibit four modular domains, that are highly conserved across species, with the BRCT (breast cancer type 1 C-terminus) domain on the C-terminus of the enzyme. In ...

Security of supply refers to governmental policies that aim to secure the availability of critical products at all times. The COVID-19 pandemic brought to fore the importance of such policies, as suddenly there was an overwhelming need for critical medical supplies that the markets were not able to fulfil. Following the pandemic, the EU has started to construct its own security of supply policy, ...

We present a multiwavelet-based implementation of a quantum/classical polarizable continuum model. The solvent model uses a diffuse solute–solvent boundary and a position-dependent permittivity, lifting the sharp-boundary assumption underlying many existing continuum solvation models. We are able to include both surface and volume polarization effects in the quantum/classical coupling, with guaranteed ...

Hybrid integration of photonic chips with electronic and micromechanical circuits is projected to bring about miniature, but still highly accurate and reliable, laser spectroscopic sensors for both climate research and industrial applications. However, the sensitivity of chip-scale devices has been limited by immature and lossy photonic waveguides, weak light–analyte interaction, and etalon effects ...