Molecular determinants involved during Staphylococcus aureus colonization and/or infection

Abstract

Given the link between the compelling impact of Staphylococcus aureus colonization on the risk and outcome of infection, strategies to prevent nasal colonization could be an appealing method of fighting infection. The ability of S. aureus to colonize and infect a host is a balance between its multitudes of virulence factors and the host immune defence mechanisms. Despite the multiple bacterial factors known to be associated with colonization, little is known about the relative contribution of the host determinants. This study explores selected molecular determinants associated with colonization and/or infection, to present a new insight on S. aureus interactions with the human host. In theory, the breakage of the interaction between host and S. aureus may open new avenues for developing novel therapeutic strategies. However, pursuit of such golden goal merits further investigations.