Browsing Universitetsbiblioteket by Author "Tveita, Torkjel"

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    • Effects of rewarming with extracorporeal membrane oxygenation to restore oxygen transport and organ blood flow after hypothermic cardiac arrest in a porcine model 

      Nilsen, Jan Harald; Schanche, Torstein Lindahl; Valkov, Sergey; Mohyuddin, Rizwan; Håheim, Brage; Kondratyev, Timofey; Næsheim, Torvind; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      We recently documented that cardiopulmonary resuscitation (CPR) generates the same level of cardiac output (CO) and mean arterial pressure (MAP) during both normothermia (38 °C) and hypothermia (27 °C). Furthermore, continuous CPR at 27 °C provides O2 delivery (ḊO2) to support aerobic metabolism throughout a 3-h period. The aim of the present study was to investigate the effects of extracorporeal ...

    • Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model 

      Schanche, Torstein Lindahl; Filseth, Ole Magnus; Østerud, Bjarne; Kondratyev, Timofey; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)
      Introduction: Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming ...

    • A novel ECG-biomarker for cardiac arrest during hypothermia 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Myles, Rachel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-10)
      <i>Background</i> - Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Main body</i> - Evaluation of ECG-data from accidental and therapeutic hypothermia patients and experimental data on ECG ...

    • Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate 

      Kuzmiszyn, Adrina Kalasho; Selli, Anders Lund; Smaglyukova, Natalia; Kondratiev, Timofei; Fuskevåg, Ole Martin; Lysaa, Roy A; Ravna, Aina Westrheim; Tveita, Torkjel; Sager, Georg; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      <p><b>Introduction:</b> Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C, due to lack of knowledge. However, previous in vivo studies have shown promising results when using phosphodiesterase 3 (PDE3) inhibitors, ...