dc.contributor.advisor | Jorde, Rolf | |
dc.contributor.author | Johnsen, Martin Solvang | |
dc.date.accessioned | 2015-10-02T14:12:43Z | |
dc.date.available | 2015-10-02T14:12:43Z | |
dc.date.issued | 2015-08-26 | |
dc.description.abstract | Background
Tromsø endocrine research group has performed multiple RCTs with vitamin D supplements/placebo and effects on different outcomes. Compiling data from four of these studies I tested an hypothesis established by Kane et al. in 2013, which suggests that vitamin D supplements have a significant lipid lowering effect in statin users. Retesting hypotheses in general is vital to the scientific community. By using patient data from Tromsø endocrine research group I wanted to retest this new hypothesis because it has not been confirmed by other studies.
Method
To test the hypothesis I pooled subjects from four vitamin D intervention studies and split the subjects into statin users and non-statin users. I then performed independent samples t-test to see if vitamin D-supplements during 6-12 months had a lipid lowering effect compared to placebo. I performed correlations between baseline levels of vitamin D and lipids. To adjust for confounding factors in the correlations I used linear regression with age, sex and BMI as covariates.
Results
At baseline serum HDL, Apo-A and triglycerides correlated significantly with vitamin D (p < 0.01). After adjusting for confounders the baseline HDL levels correlated significantly with vitamin D (p=0.001). I found no significant results in the t-test or the linear regressions on changes in lipid levels based on vitamin D treatment. Conclusions
I found no clear significant lipid-lowering effect of vitamin D supplementation compared to placebo in neither statin users nor non-statin users. After adjusting for confounders, serum HDL still remained significantly correlated with vitamin D at baseline. | en_US |
dc.identifier.uri | https://hdl.handle.net/10037/8179 | |
dc.identifier.urn | URN:NBN:no-uit_munin_7764 | |
dc.language.iso | eng | en_US |
dc.publisher | UiT Norges arktiske universitet | en_US |
dc.publisher | UiT The Arctic University of Norway | en_US |
dc.rights.accessRights | openAccess | |
dc.rights.holder | Copyright 2015 The Author(s) | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/3.0 | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) | en_US |
dc.subject.courseID | MED-3950 | en_US |
dc.subject | Statin | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | VDP::Medisinske Fag: 700 | en_US |
dc.subject | VDP::Medical disciplines: 700 | en_US |
dc.title | No lipid lowering effect of vitamin D supplements found on statin users. | en_US |
dc.type | Master thesis | en_US |
dc.type | Mastergradsoppgave | en_US |