• Health-related quality of life on tele-monitoring for users with pacemakers 6 months after implant: the NORDLAND study, a randomized trial 

      Lopez-Villegas, Antonio; Catalán-Matamoros, Daniel; Lopez-Liria, Remedios; Enebakk, Terje; Thunhaug, Hilde; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Background</i>: With an ageing population and widening indications for pacemakers implantation, the number of persons carrying an implant is steadily increasing. The routine follow-up is thus a heavy burden for the respective NHS as well as for the patients and their relatives. Most of them of the studies have been performed in densely populated areas and nearby to the hospital. It is thus ...
    • High-density lipoprotein subfractions: Much ado about nothing or clinically important? 

      Lappegård, Knut Tore; Kjellmo, Christian Abendstein; Hovland, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
      High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been ...
    • Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy 

      Lappegård, Knut Tore; Pop-Purceleanu, Monica; van Heerde, Waander L.; Sexton, Joseph; Tendolkar, Indira; Pop, Gheorghe A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new or recurrent AF. However, it is not known whether ...
    • In need of percutaneous coronary intervention in an arctic setting– patients’ experience of safety and quality of care: a qualitative study 

      Krane, Anette; Pettersen, Gunn; Lappegård, Knut Tore; Hanssen, Tove Aminda (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-29)
      Patients with coronary heart disease need timely treatment for survival and optimum prognosis. There is limited research exploring patients’ experience regarding distance to percutaneous coronary intervention. The aim was to explore patients’ experiences of aspects contributing to safety and quality of care regarding health services following percutaneous coronary intervention in Northern Norway. A ...
    • Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure 

      Nendl, Andraz; Raju, Sajan; Broch, Kaspar; Mayerhofer, Christiane Caroline; Holm, Kristian; Halvorsen, Bente; Lappegård, Knut Tore; Moscavitch, Samuel; Hov, Johannes Espolin Roksund; Seljeflot, Ingebjørg; Trøseid, Marius; Awoyemi, Ayodeji Olawale (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)
      Background: The gut microbiota in patients with chronic heart failure (HF) is characterized by low bacterial diversity and reduced ability to synthesize beneficial metabolites. These changes may facilitate leakage of whole bacteria or bacterial products from the gut into the bloodstream, which may activate the innate immune system and contribute to the low-grade inflammation seen in HF. In this ...
    • Level of education is associated with coronary heart disease and chronic kidney disease in individuals with type 2 diabetes: a population-based study 

      Slåtsve, Kristina Barbara; Claudi, Tor; Lappegård, Knut Tore; Jenum, Anne Karen; Larsen, Marthe-Kristin; Nøkleby, Kjersti; Tibelles, Hatuia Bø; Cooper, John; Sandberg, Sverre; Buhl, Esben Selmer; Løvaas, Karianne Fjeld; Berg, Tore Julsrud (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      Introduction - To study the relationship between education level and vascular complications in individuals with type 2 diabetes in Norway.<p> <p>Research design and methods - Multiregional population-based cross-sectional study of individuals with type 2 diabetes in primary care. Data were extracted from electronic medical records in the period 2012–2014. Information on education level was obtained ...
    • Long-Term Socioeconomic Impact of Informal Care Provided to Patients with Pacemakers: Remote vs. Conventional Monitoring 

      Cesar, Leal-Costa; Lopez-Villegas, Antonio; Catalan-Matamoros, Daniel; Robles-Musso, Emilio; Lappegård, Knut Tore; Rafael Jesus, Bautista-Mesa; Salvador, Peiró; Remedios, Lopez-Liria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-16)
      The impact of informal care immediately after pacemaker (PM) implantation has been well established; however, not much is known about its long-term effects. The present study compared personal characteristics, associated problems, workloads, time, and costs related to informal care provided to patients with PM under remote monitoring (RM) vs. conventional monitoring (CM) in the hospital, five ...
    • Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

      Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-15)
      Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation from carnitine is via the microbiota-dependent intermediate g-butyrobetaine (gBB). Elevated TMAO levels are associated with cardiovascular disease (CVD), but little ...
    • No effect of omega-3 polyunsaturated fatty acid supplementation on inflammatory markers in familial hypercholesterolemia: a randomized crossover trial 

      Hande, Liv Nesse; Thunhaug, Hilde; Ludviksen, Judith K; Hovland, Anders Wilhelm; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Individuals with familial hypercholesterolemia (FH) have increased cardiovascular risk despite lipid-lowering therapy, and additional therapy is warranted. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements have demonstrated an effect on cardiovascular endpoints in some clinical trials. Platelet-modifying and anti-inflammatory properties are among the proposed beneficial effects of n-3 PUFA. ...
    • Pacemaker implantation in small hospitals : complication rates comparable to larger centres 

      Haug, Bjørn; Kjelsberg, Kjærsti; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Some countries have a demography that makes it necessary to maintain relatively small pacemaker centres. We wanted to assess the quality of pacemaker surgery in two such hospitals. Through patient records we gathered information on ∼535 consecutive primary pacemaker implantations in two small pacemaker centres with 30 and 80 annual operations, respectively. All patients were followed for 3 years. ...
    • Patients' experiences of remote communication after pacemaker implant: The NORDLAND study 

      Catalán-Matamoros, Daniel; Lopez-Villegas, Antonio; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
      <i>Background</i> - The concept of ‘patient experience’ has become central to how to improve healthcare. Remote communication with patients is today a frequent practice in healthcare services, showing similar outcomes to standard outpatient care while enabling cost reduction in both formal and informal care. The purpose of this study was to analyse the experiences of people with telemonitoring ...
    • Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity: Evidence from bariatric surgery 

      Trøseid, Marius; Nestvold, Torunn Kristin; Rudi, Knut; Thoresen, Hanna; Nielsen, Erik Waage; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-15)
      OBJECTIVE It is of vital importance to elucidate the triggering factors of obesity and type 2 diabetes to improve patient care. Bariatric surgery has been shown to prevent and even cure diabetes, but the mechanism is unknown. Elevated levels of lipopolysaccharide (LPS) predict incident diabetes, but the sources of LPS are not clarified. The objective of the current study was to evaluate the ...
    • Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention–a pilot trial 

      Larsen, Christopher Storm; Hande, Liv Nesse; Kummen, Martin; Thunhaug, Hilde; Vestad, Beate; Hansen, Simen Hyll; Hovland, Anders Wilhelm; Trøseid, Marius; Lappegård, Knut Tore; Hov, Johannes Espolin Roksund (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-01)
      Individuals with familial hypercholesterolemia (FH) undergo an aggressive treatment with cholesterollowering drugs to prevent coronary heart disease. Recent evidence suggests an interplay between the gut microbiota, blood lipid levels and lipid-lowering drugs, but this has yet to be studied in individuals with FH. The objective of the study was to characterize the gut microbiota of individuals ...
    • Remote Monitoring of CIEDs—For Both Safety, Economy and Convenience? 

      Lappegård, Knut Tore; Moe, Frode (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-28)
      Cardiac implantable electronic devices such as pacemakers and defibrillators are increasingly monitored by systems transmitting information directly from the patient to the hospital. This may increase safety and patient satisfaction and also under certain circumstances represent an economic advantage. The review summarizes some of the recent research in the field of remote monitoring of cardiac devices.
    • Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial 

      Awoyemi, Ayodeji Olawale; Mayerhofer, Cristiane; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hovland, Anders; Halvorsen, Sigrun; Halvorsen, Bente; Gregersen, Ida; Svardal, Asbjørn M.; Berge, Rolf Kristian; Hansen, Simen Hyll; Götz, Alexandra; Holm, Kristian; Aukrust, Pål; Åkra, Sissel; Seljeflot, Ingebjørg; Solheim, Svein; Lorenzo, Andrea; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)
      Background - The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast Saccharomyces boulardii have been suggested to improve left ventricular ejection fraction (LVEF).<p> <p>Methods - In a multicentre, prospective randomized open label, blinded ...
    • Symptoms of Depression, Anxiety, and Posttraumatic Stress among Patients with Cardiac Pacemakers 

      Bürker, Britta Susanne; Halvorsen, Randolf Inge; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-15)
      Despite being a prerequisite for tailoring specific therapeutic interventions, knowledge of pattern and prevalence of clinically significant psychiatric symptomatology among patients with cardiac pacemakers (PMs), especially of symptoms of posttraumatic stress, is limited. We studied symptoms of depression, anxiety, and posttraumatic stress among PM patients (PM due to syncope or presyncope) ...
    • Telemonitoring and quality of life in patients after 12 months following a pacemaker implant: The Nordland study, a randomised trial 

      Lopez-Liria, Remedios; Lopez-Villegas, Antonio; Enebakk, Terje; Thunhaug, Hilde; Lappegård, Knut Tore; Catalán-Matamoros, Daniel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-05)
      The purpose of this study was to analyse the health-related quality of life (HRQoL) of patients followed up using a remote device-monitoring system (TM) compared to patients followed up through standard outpatient visits (HM), 12 months after the implantation of a pacemaker. This was a trial design that used the EuroQol-5D Questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLHF). ...
    • The total prevalence of diagnosed diabetes and the quality of diabetes care for the adult population in Salten, Norway 

      Slåtsve, Kristina Barbara; Claudi, Tor; Lappegård, Knut Tore; Jenum, Anne Karen; Larsen, Marthe; Cooper, John; Sandberg, Sverre; Berg, Tore Julsrud (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-27)
      <p><i>Objective:</i> To assess the total prevalence of types 1 and 2 diabetes and to describe and compare cardiovascular risk factors, vascular complications and the quality of diabetes care in adults with types 1 and 2 diabetes in Salten, Norway. <p><i>Research design and methods:</i> Cross-sectional study including all patients with diagnosed diabetes in primary and specialist care in Salten, ...