Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is incorporated into proteins after it is attached to its tRNA by tryptophanyl-tRNA synthestases. As ...

Denne avhandlingen er basert på fire sedimentkjerner fra et område ved Vest Svalbard hvor metan siver opp fra havbunnen. Studien fokuserer på å rekonstruere graden av metanutsiving i fortiden, samt klimavariasjoner i Arktiske strøk med bruk av bentiske foraminiferer. Foraminiferer er encellede organismer som produserer en kalkholdig skall som bevares i sedimentene på havbunnen. Ved å se på geokjemiske ...

<p><i>Cuscuta</i> is a genus of parasitic plants that form cross-species bridges and connect to the xylem and phloem of a wide variety of host plants. Because of their unique lifestyle, research into processes like the formation of connections in between plant cells and plant immunity would benefit from <i>Cuscuta</i> as a model system. However, a method to study gene functions in a <i>Cuscuta</i> ...

We see from information published elsewhere that Gold OA is on the increase globally. The OA Diamond study indicates that Diamond OA is an important component of scholarly communications, with an estimated 8–9% of the total global scholarly output. These numbers, however, are on a global scale and are not necessarily representative of any given country; country case studies are needed to find this ...

The purpose of this study was to evaluate the importance of exogenous water intake (snow/seawater) in hooded seal (Cystophora cristata) pups during their postweaning fast. In this study, five hooded seal pups had ad lib access to snow and seawater for the first 12 and last 21 days of their post-weaning fast, respectively. Total body water and water flux were determined during both exposure periods ...

Increasingly advanced and affordable close-range sensing techniques are employed by an ever-broadening range of users, with varying competence and experience. In this context a method was tested that uses photogrammetry and classification by machine learning to divide a point cloud into different surface type classes. The study site is a peat scarp 20 metres long in the actively eroding river bank ...

The performance of relativistic density functional theory (DFT) methods has been investigated for the calculation of the recently measured hyperfine coupling constants of hexafluorido complexes [ReF₆ ] ^2- and [IrF₆ ] ^2- . Three relativistic methods were employed at the DFT level of theory: the 2-component zeroth-order regular approximation ...

In order to investigate the effect of glacial water on the CO₂ system in the fjord, we studied the variability of the total alkalinity (A_T), total dissolved inorganic carbon (C_T), dissolved inorganic nutrients, oxygen isotopic ratio (δ¹⁸O), and freshwater fractions from the glacier front to the outer Tempelfjorden on Spitsbergen in winter 2012 (January, ...

Background: Results from several cohort and case–control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered.<p> <p>Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma ...

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.<p> <p>Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics ...