Purpose: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections ...

The subject of the article is how digital structure and predictability affects the learning environment. This is key knowledge as regards both class management and learning. An intervention research design was employed. The intervention aimed to test digital aids in a mainstream class: a digital day planner board and a Time timer wristwatch with a countdown function. These aids are usually ...

Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke.<p> <p>Design Multicentre case-cohort study.<p> <p>Setting A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European ...

Background: Von Willebrand factor (VWF) stabilizes factor VIII in the circulation and prevents its premature clearance.<p><p> Objective: To study the effects of VWF on FVIII clearance in rats with endogenous VWF.<p><p> Methods: Anatomical and hepatocellular distribution studies were performed in rats following intravenous administration of glycoiodinated recombinant FVIII (rFVIII) and a ...

Research substantiates children of parents with mental disorders including substance abuse face increased risk for emotional and behavioral problems. Although evidence suggests that support programs for children enhance resiliency, recruiting children to these groups remains problematic. This study identifies successful recruitment strategies for prevention programs for children of parental ...

Parasite distribution patterns in lotic catchments are driven by the combined influences of unidirectional water flow and the mobility of the most mobile host. However, the importance of such drivers in catchments dominated by lentic habitats are poorly understood. We examined parasite populations of Arctic charr Salvelinus alpinus from a series of linear-connected lakes in northern Norway to ...

Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.<p> <p>Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided selfreported ...

Many marine species are known to change their distribution in response to changing climatic conditions. One such example is the blue mussel Mytilus spp., spreading northward coincident with an increase in ocean temperatures. On Svalbard, the frst living specimens of Mytilus spp. were discovered in 2004. Here we present an analysis of the current distribution of Mytilus spp. on Svalbard, with a ...

Background: Individuals suffering from schizophrenia have a reduced life expectancy with cardiovascular disease (CVD) as a major contributor. Low educational attainment is associated with schizophrenia, as well as with all-cause and CVD mortality. However, it is unknown to what extent low educational attainment can explain the increased mortality in individuals with schizophrenia.<p> <p>Aim: Here, ...

Previous research has demonstrated that age-related decline in cognitive and sensorimotor functions are related to dexterity and instrumental activities of daily living (IADL). Few studies have closely investigated the association between dexterity and cognitive functions. The purpose of this study was to explore possible differences in dexterity, cognition and IADL function across a group of mild ...