Background: Excessive bradykinin (BK) generation from high molecular weight kininogen (HK) by plasma kallikrein (PK) due to lack of protease inhibition is central to the pathophysiology of hereditary angioedema (HAE). Inadequate protease inhibition may contribute to HAE through a number of plasma proteases including factor VII activating protease (FSAP) that can also cleave HK.<p> <p>Objective: ...

Hypothermia was increasingly proposed as a neuroprotective therapy in the 1990s, culminating in the publication of two randomized trials in 2002, which showed beneficial effects of therapeutic hypothermia in comatose survivors of cardiac arrest.1,2 Therapeutic hypothermia was subsequently included in guidelines for the treatment of this patient group. However, doubt as to whether hypothermia provided ...

This article discusses how to live with differences while maintaining differences in an international embroidery workshop in Tromsø, Norway. It explores the role of art in enabling interactions between strangers, showing how individuals become part of collectives and facilitate social change. This collaboration between artist and researcher draws on data from arts-based participant observations and ...

Within the coastal zone, oceanographic features, such as fronts, can have major effects on the abundance and distribution of larval fish. We investigated the effects of fronts on larval fish assemblages by jointly collecting physical (ADCP and CTD) and biological (larvae) data in the nearshore waters of the south coast of South Africa, on four separate neap-tide occasions. Accumulation of fish larvae ...

A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional ...

Background: The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories that might be clinically relevant, by exploring systems biological databases.<p> <p>Methods: Eight females were recruited by volunteer request. Peripheral venous whole blood was ...

The prediction of efficiency scores for winter road maintenance (WRM) is a challenging and serious issue in countries with cold climates. While effective and efficient WRM is a key contributor to maximizing road transportation safety and minimizing costs and environmental impacts, it has not yet been included in intelligent prediction methods. Therefore, this study aims to design a WRM ...

Genus Aliivibrio is known to harbor species exhibiting bioluminescence as well as pathogenic behavior affecting the fish farming industry. Current phylogenetic understanding of Aliivibrio has largely remained dormant after reclassification disentangled it from the Vibrio genus in 2007. There is growing evidence of wider diversity, but until now the lack of genomes and selective use of type strains ...

Chris Armstrong argues that attempts at justifying special claims over natural resources generally take one of two forms: arguments from improvement and arguments from attachment. We argue that Armstrong fails to establish that the distinction between natural resources and improved resources has no normative significance. He succeeds only in showing that ‘improvers’ (whoever they may be) are ...

Over the past 10 years, Oosterhof and Todorov’s valence–dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We ...