<p><i>Background: </i>Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer’s disease (AD) pathology. <p><i>Objective:</i> To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology. <p><i>Methods: </i>We identified ...

The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

<i>Background</i>: Psychological online interventions (POIs) could represent a promising approach to narrow the treatment gap in psychosis but it remains unclear whether improving mindfulness functions as a mechanism of change in POIs. For the present study, we examined if mindfulness mediates the effect of a comprehensive POI on distressing (auditory) hallucinations.<p> <p><i>Methods</i>: We ...

Finite adjunct clauses are often assumed to be among the strongest islands for filler–gap dependency creation cross-linguistically, but Kush, Lohndal & Sprouse (2019) found experimental evidence suggesting that finite conditional <i>om</i>-adjunct clauses are not islands for topicalization in Norwegian. To investigate the generality of these findings, we ran three acceptability judgment experiments ...

I denne fokusspalten tar vi for oss hvordan den norske nordområdepolitikken har blitt kommunisert gjennom bruk av politiske «narrativer». Ved bruk av narrativ politisk analyse belyser vi bruk av ideer om fortid, nåtid og fremtid i og som «nord». Innenriks har dette betydd en gjenfortelling av identitet og økt oppmerksomhet på elementer som hav- og kysthistorie, og utenriks har det betydd en reevaluering ...

A highly sensitive integrated photonic transducer is designed by utilizing asymmetric long-period gratings on a silicon waveguide. These gratings are formed by periodic perturbation of the waveguide width, leading to coupling between the fundamental mode and the 1st order asymmetric leaky mode. The coupled modes are studied via finite-element and finite-difference time-domain methods. Only a single ...

<i>Background</i> - Human skeletal muscle responds to weight-bearing exercise with significant inter-individual differences. Investigation of transcriptome responses could improve our understanding of this variation. However, this requires bioinformatic pipelines to be established and evaluated in study-specific contexts. Skeletal muscle subjected to mechanical stress, such as through resistance ...

Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. ...

Studien belyser tre kvinners opplevelser av at deres selvstendige ektefeller får slag og blir sterkt pleietrengende, samt hvordan de opplever samhandlingen med helse- og omsorgstjenesten. Det er benyttet en hermeneutisk- fenomenologisk tilnærming og semistrukturerte kvalitative intervju. Funnene viser at kvinnene opplever utmattelse, usikkerhet og hjelpeløshet i sin egen rolle som ektefelle, mor og ...

<i>Objectives</i> - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. <p> <p><i>Design and setting</i> - A populations-based cohort study with repeated measurements, the Tromsø Study. <p> <p><i>Primary outcome measure</i> - Myocardial infarction. <p> <p>< ...