Stanozolol is still the most commonly used illicit anabolic‐androgenic steroid (AAS) in professional sports. Therefore, accurate and fast analysis and long detection windows are of great interest in the field of antidoping analysis. In this work, a very simple, fast, and highly sensitive online solid‐phase extraction method coupled with liquid chromatography–high‐resolution tandem mass spectrometry ...

We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin‐releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised in 20–67 % overall yield with the aim of identifying a high‐affinity antagonist capable of crossing the blood–brain barrier. Binding affinity to rat GnRH−R was determined by ...

<i>Topic</i> - A substantial number of patients die in the intensive care unit, so high-quality end-of-life care is an important part of intensive care unit work. However, end-of-life care varies because of lack of knowledge of best practices.<p> <p><i>Clinical Relevance</i> - Research shows that high-quality end-of-life care is possible in an intensive care unit. This article encourages nurses ...

<i>Aim</i> - To study whether a simple targeted intervention could reduce unwarranted antibiotic treatment in near‐term and term neonates with suspected, but not confirmed early‐onset sepsis.<p> <p><i>Methods</i> - A quality improvement initiative in three Norwegian neonatal intensive care units. The intervention included an inter‐hospital clinical practice guideline for discontinuing antibiotics ...

Neoproterozoic metasedimentary rocks in the foreland domains of the Kaoko–Dom Feliciano–Gariep orogenic system record sedimentation from the breakup of Rodinia to the amalgamation of Gondwana, and thus provide ideal subjects for investigation of the mutual pre-orogenic positions of rifted margins of the African and South American cratonic blocks. U–Pb isotopic dating of zircon in the Brusque Complex ...

Wind power development, whilst welcomed by many as a potentially green source of energy, also gives rise to considerable local resistance. Drawing on three case studies from coastal Norway (Frøya, Haramsøy, and Egersund), the present article sets out to reflect on life in anticipation of wind power development. Reflecting on the nature of life in anticipation of undesired wind power developments, ...

Background: Back pain is a very common disability. 60-80% of the population in Norway will experience LBP during their life. 30-50% of all people report neck pain during a year. Most back pain has no pathoanatomical diagnosis and is considered a multifactorial condition where biopsychosocial factors influence pain. “Yellow flags” are used in guidelines referring to psychosocial risk-factors for ...

The Arctic region shows some of the world's most significant signs of climate change; for instance, a negative trend in summer sea‐ice cover of around 15% per decade and Arctic amplified surface‐air warming that is three times the global average. The atmospheric energy transport plays an important role in the Arctic climate. Recently a Fourier‐based method for studying the atmospheric energy transport ...

Aiming for sustainable development of food value chains several assessment methods are developed, however it seems challenging to go from assessment to actual change. A solution proposed is increased stakeholder involvement also in the assessment phase. The perspective on sustainability varies depending on several variables, among which the geographical context where the producers are located. The ...

<i>Objectives</i> - The normal female external anal sphincter (EAS) is shorter anteriorly than laterally and posteriorly. Furthermore, the thickness of the very proximal part of the circular EAS is thinner than 50% of the lateral and posterior EAS thickness. The extent of these features is not fully explored. The aim of this prospective study was to assess the normal anal sphincter with 3‐dimensional ...