Digital twin type models can be developed for physical systems that are complex nonlinear a system of systems (SoS). However, such models are usually difficult to represent by linear equations. Therefore, an adequate linearization technique should be introduced. Therefore, linear models as digital twins can be interpreted easily and need much less computational power when applied to various industrial ...

Cells in living organisms are dynamic compartments that continuously respond to changes in their environment to maintain physiological homeostasis. While basal autophagy exists in cells to aid in the regular turnover of intracellular material, autophagy is also a critical cellular response to stress, such as nutritional depletion. Conversely, the deregulation of autophagy is linked to several diseases, ...

Antimicrobial peptides (AMPs) can kill bacteria by destabilizing their membranes, yet translating these molecules’ properties into a covalently attached antibacterial coating is challenging. Rational design efforts are obstructed by the fact that standard microbiology methods are ill-designed for the evaluation of coatings, disclosing few details about why grafted AMPs function or do not ...

When assessing a risk, a future event, uncertainty is vital as we cannot know what will happen. Having an active relationship to uncertainty can reduce it and help the decision-makers make informed decisions. Avalanche forecasting is widely used by outdoor recreational and local authorities for emergency preparedness use. Therefore, an additional focus on uncertainty in this field benefits people ...

In Graph Neural Networks (GNNs), hierarchical pooling operators generate local summaries of the data by coarsening the graph structure and the vertex features. While considerable attention has been devoted to analyzing the expressive power of message-passing (MP) layers in GNNs, a study on how graph pooling affects the expressiveness of a GNN is still lacking. Additionally, despite the recent advances ...

Large mammalian herbivores (LMH) shape vertebrate communities and structure food webs in many terrestrial ecosystems. However, the mechanisms that underlie the effects of LMH on other vertebrates are poorly understood. In France, domestic LMH have grazed alpine and mountain grasslands for thousands of years, profoundly influencing landscapes and wildlife. As LMH modify habitat structure, favour ...

This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects ...

This chapter discusses L3/Ln acquisition as a step-by-step acquisition process, where crosslinguistic influence is considered to be the result of co-activation of lexical items and syntactic structures of the previously acquired languages in processing. That is, as argued by the Linguistic Proximity Model and the Scalpel Model, L3/Ln acquisition is learning by parsing/processing. The main focus of ...

After twenty years of war, in August 2021, the United States withdrew from Afghanistan, the Afghan forces surrendered, and the Taliban regained power over Afghanistan (Yousaf and Jab-arkhail 2021, 1). The resulting security risks extend beyond the borders of Afghanistan (Verma 2022, 152). Consequently, the events received extensive attention in the media outlets in the region. This research analyses ...

Civil wars have the potential to produced devastating impacts, including increasing the number of people seeking asylum abroad. Forcibly displaced people usually carry vulnerabilities and are at greater risk of developing common and severe mental health disorders, due to stress and traumatic situations experienced prior to their flight or even after arriving at the host country, all of that combined ...