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norskMunin: Recent submissions
Now showing items 961-980 of 37183
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Hypothetical target trial emulation assessing of combination pembrolizumab with chemotherapy in NSCLC with frail patients
(Mastergradsoppgave; Master thesis, 2024-05-14)Real-world data (RWE) may enable the investigation of patients who are ineligible for Randomized Controlled Trials (RCT) due to poor performance status, old age, or comorbidities. In addition, it permits research that may be impossible through prospective design due to ethics or feasibility. Hypothetical target trial emulation(hTTE) has emerged as a new method that uses RWD to evaluate new drugs' ... -
Mulighetsstudie på plusshus i arktisk klima
(Master thesis; Mastergradsoppgave, 2021-05-14)Globalt står byggesektoren for over en tredjedel av energibruken, og nesten 40 prosent av det totale CO2-utslippet. På bakgrunn av miljøpåvirkningen byggesektoren har, er fokus på mindre utslipp og mer energieffektive bygg viktige tema i det grønne skifte. Plusshus er en sterk pådriver i dette skifte og det er viktig å belyse mulighetene for denne type bygg. Denne mulighetsstudien har som hensikt ... -
Utvisning av utlendinger med barn i Norge. Barnets beste i forholdsmessighetsvurderingen
(Mastergradsoppgave; Master thesis, 2022-05-14)Avhandlingen gir en fremstilling av de regler som gjelder ved utvisning av utlendinger som har barn i Norge. Formålet med fremstillingen er å undersøke hvor tungtveiende barnets interesser må være for å trumfe de hensyn som tilsier at forelderen bør utvises. -
The Role of Ballasting, Seawater Viscosity and Oxygen-Dependent Remineralization for Export and Transfer Efficiencies in the Global Ocean
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-05)The particulate organic carbon (POC) flux from the euphotic zone to the deep ocean is central to the biological carbon pump. It is typically evaluated using “export efficiency” and “transfer efficiency,” which reflect POC formation and sinking and carbon sequestration efficiency in the ocean's interior, respectively. Since observations of these metrics are limited, biogeochemical models can elucidate ... -
Physical activity, endurance sport practice, atrial fibrillation, and prevention of adverse events: The Norwegian Exercise in Atrial Fibrillation Study (NEXAF)
(Doctoral thesis; Doktorgradsavhandling, 2025-05-27)Atrial fibrillation (AF), the most common arrhythmia worldwide, is associated with an increased risk of stroke and mortality. Low to moderate physical activity (PA) levels are associated with a reduced AF risk. Conversely, high PA is associated with an increased risk. Thus, it is unclear whether the beneficial effect of high PA is offset by an increased AF risk. Furthermore, the impact of PA on ... -
En analyse av avtl. § 36 som rettslig grunnlag for tilsidesettelse av ansvarsfraskrivelser i kommersielle kontraktsforhold
(Master thesis; Mastergradsoppgave, 2024-05-11)Oppgaven har til hensikt å analysere de ulike problemstillingene som oppstår når kommersielle parter inkluderer ansvarsfraskrivelser i avtaler de inngår. Sentralt i denne oppgaven er spenningen mellom avtalefriheten og de juridiske begrensningene som foreligger på rettsområdet. -
On the appetites of small copepods and nematodes in the Arctic Barents Sea and Nansen Basin: In situ trophic interactions revealed by brute force prey metabarcoding
(Doctoral thesis; Doktorgradsavhandling, 2025-05-26)Small invertebrates (≤ 2 mm) are key members of the Arctic marine ecosystem, yet their trophic interactions have rarely been researched due to methodological challenges. In this thesis, a novel brute force approach to prey metabarcoding was developed and applied to characterize the trophic interactions of small pelagic copepods and benthic nematodes over four seasons in the Barents Sea and Nansen ... -
Synthesis of linear and cyclic proline-rich analogues of the marine, antimicrobial peptides Hyasin 1 and Arasin 1. Impact of antimicrobial peptide modifications on bioactivity and toxicity
(Master thesis; Mastergradsoppgave, 2022-05-13)Since the introduction of antimicrobial agents in the 1940s, antimicrobial resistance has increasingly become a major concern. New resistance mechanisms have emerged and threatened our ability to treat common infections. Currently, antimicrobial resistance is rising to higher levels in all parts of the world and the need of novel therapeutics is increasing. As a contribution to antimicrobial drug ... -
The potential of ChatGPT as a learning tool. A randomized controlled trial of pharmacy students in Tromsø
(Master thesis; Mastergradsoppgave, 2024-05-12)Background: Pharmacy education is evolving with technological advances and changing student needs, incorporating digital tools alongside traditional methods. Artificial intelligence (AI), particularly large language models like ChatGPT, offers interactive learning and real-time feedback, shifting from passive to active learning. However, there is a notable lack of research-based evidence on ChatGPT’s ... -
Understanding how community pharmacist play a role in self-medication with antibiotics in Kumasi, Ghana.
(Mastergradsoppgave; Master thesis, 2024-05-15)Background: Non-prescription antibiotic dispensing is a widespread phenomenon observed predominantly in low- and middle-income countries (LMICs) and low-income countries (LICs). This practice is associated with inappropriate sale and usage of antibiotics, contributing significantly to the global challenge of antibiotic resistance. Aim: The aim of the study is to investigate how the pharmacist ... -
Patient selection in target trial emulation using data from Cancer registry of Norway
(Mastergradsoppgave; Master thesis, 2024-05-15)Background: Breast cancer is a significant public health challenge with diverse treatment outcomes. This underscores the need for better patient selection in clinical trials to improve representativeness and treatment efficacy. This thesis uses data from the Cancer Registry of Norway (CRN) to assess how modifications to eligibility criteria, as outlined in the PALOMA-II randomized controlled trial, ... -
Retur av legemidler til apotek i Tromsø
(Mastergradsoppgave; Master thesis, 2024-05-14)BAKGRUNN: Befolkningsvekst, utvikling av legemidler og helsetjenester, flere eldre og kronisk syke har blant annet ført til økt bruk av legemidler. Som følge av dette øker også mengden legemiddelavfall. Legemidler er avgjørende for mennesker og dyr sin helse, men de utgjør også en bekymring dersom de havner i miljøet. Studier har vist at den finansielle verdien av returnerte legemidler til apotek ... -
Exploring the viability of using liposomes and bacterial extracellular vesicles (bEVs) in interaction studies by calorimetric methods
(Mastergradsoppgave; Master thesis, 2024-05-14)The increasing level of AMR require an increase in new antimicrobial drug candidates. By proving that bEVs are a suitable model for the bacterial membrane, it can be applied to the development of new drug candidates. Potentially making the development of new candidates more efficient and reducing cost. To further examine the potential of bEVs, we isolated bEVs from E. coli, a gram-negative bacteria. ... -
Expression and characterization of recombinant mouse and human DUSP2 protein
(Mastergradsoppgave; Master thesis, 2023-09-15)Background: This master's thesis focuses on the DUSP2 phosphatase protein. This protein plays a vital role in regulating cellular signaling pathways, including MAPK signaling involving JNK1, p38α, and ERK2. By better understanding DUSP2's physiological role within these pathways, we can gain a deeper understanding of cellular mechanisms, disease mechanisms, and perhaps even pave the way for new drugs ... -
Phenotypic and genotypic characterization of biofilm formation in clinical Escherichia Coli isolates from Norwegian hospitals.
(Mastergradsoppgave; Master thesis, 2023-09-15)Biofilm is an extracellular matrix that allows bacteria to attach themselves to surfaces and to each other. Biofilm formation among E. coli causes diseases, and the majority of urinary tract infections (UTI) are caused by biofilm producing E. coli. The biofilm layer among E. coli also play a role in bloodstream infections (BSI). Biofilms adhere to surfaces as indwelling medical devices and increase ... -
Morphology and Holocene activity of a high-latitude canyon – channel system: The proximal Lofoten Basin channel system (Norwegian Sea)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-04-30)Canyon – channel systems have the potential to be biological and marine litter “hotspots”, and they can act as important carbon sinks. However, knowledge about the modern (Holocene) activity of many of these systems remains poor. This includes the high-latitude Andøya Canyon - Lofoten Basin Channel located in the Norwegian Sea (∼69oN). This study focuses on the proximal Lofoten Basin Channel and ... -
Environmental effects monitoring of offshore oil and gas activities on the Norwegian continental shelf: A review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-04-24)This review examines the evolution and findings of Norway's offshore environmental monitoring (OEM) program over the past five decades. The program targets soft sediments, water column organisms, and deep-water epifauna across the Norwegian Continental Shelf (NCS) to assess the impacts of offshore oil and gas activities. The program is required by Norwegian authorities and financed by oil and gas ... -
Prevalence and density of Elaphostrongylus rangiferi larvae in faecal samples of semi-domestic reindeer (Rangifer tarandus tarandus) in Norway 2013-16
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-21)Background - The reindeer brainworm, Elaphostrongylus rangiferi, is a protostrongylid parasite of reindeer that has caused severe disease outbreaks in reindeer husbandry. E. rangiferi is considered ubiquitous in Norway, though most published prevalence studies are from Finnmark county only. In the present study, faecal samples were collected over three winter seasons (2013–2016) from eight herds of ... -
Southern Ocean Carbon Export Revealed by Backscatter and Oxygen Measurements From BGC-Argo Floats
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-04-28)The Southern Ocean (south of 30°S) contributes significantly to global ocean carbon uptake through the solubility, physical and biological pumps. Many studies have estimated carbon export to the deep ocean, but very few have attempted a basin-scale perspective, or accounted for the sea-ice zone (SIZ). In this study, we use an extensive array of BGC-Argo floats to improve previous estimates of carbon ... -
Contextually determined or semantically distinct? The competition between instrumental, long form nominative and short form nominative in Russian predicate adjectives
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-03-19)Based on data from the syntactic subcorpus of the Russian National Corpus, we undertake a quantitative analysis of the competition between Russian predicate adjectives in the instru- mental (e.g., pustym ‘empty’), the long form nominative (e.g., pustoj ‘empty’), and the short form nominative (e.g., pust ‘empty’). It is argued that the choice of adjective form is partly determined by the context. ...
