Viser treff 1021-1040 av 36163

    • Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-21)
      BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients. The closely related simian polyomavirus SV40 is known to cause cytoplasmic vacuolization in simian kidney cells, possibly increasing progeny release and cell death. This study aimed to determine whether BKPyV causes ...
    • Care Convoys and Solitary Vessels: Navigating Family Care for Older Adults Living With Dementia in Arctic Norway 

      Blix, Bodil Hansen; Ågotnes, Gudmund (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-09)
      Drawing on the metaphor of “care convoys,” this study explores the experiences and strategies of family caregivers of older adults with dementia in rural areas of Northern Norway. The study is part of a broader project that investigates how these older adults and their caregivers use or do not use municipal health and care services. We conducted qualitative in-depth interviews with 11 family caregivers ...
    • Synthesis, Electrochemistry and Density Functional Theory of Osmium(II) Containing Different 2,2′:6′,2″-Terpyridines 

      Mateyise, Nandisiwe G. S.; Conradie, Marrigje M.; Conradie, Jeanet (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-27)
      In coordination chemistry, 2,2′:6′,2″-terpyridine is a versatile and extensively studied tridentate ligand. Terpyridine forms stable complexes with a variety of metal ions through coordination sites provided by the three nitrogen atoms in its pyridine rings. This paper presents an electrochemical study on various bis(terpyridine)osmium(II) complexes, addressing the absence of a systematic investigation ...
    • Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma 

      Emaldi, Maite; Rey-Iborra, Esther; Marín, Ángela; Mosteiro, Lorena; Lecumberri, David; Øyjord, Tove Ragnhild; Roncier, Noémie; Mælandsmo, Gunhild Mari; Angulo, Javier C.; Errarte, Peio; Larrinaga, Gorka; Pulido, Rafael; López, José I.; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)
      Immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) are improving the response rates of advanced renal cancer patients. However, many treated patients do not respond, making novel immune checkpoint-based immunotherapies potentially clinically beneficial only for specific groups of patients. We detected high expression of the immune checkpoint protein B7-H3 in clear ...
    • Characterizing the Impact of Physical Activity on Patients with Type 1 Diabetes Using Statistical and Machine Learning Models 

      Chushig-Muzo, David; Calero-Díaz, Hugo; Fabelo, Himar; Årsand, Eirik; van Dijk, Peter Ruben; Soguero-Ruiz, Cristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-29)
      Continuous glucose monitoring (CGM) represents a significant advancement in diabetes management, playing an important role in glycemic control for patients with type 1 diabetes (T1D). Despite their benefits, their performance is affected by numerous factors such as the carbohydrate intake, alcohol consumption, and physical activity (PA). Among these, PA could cause hypoglycemic episodes, which ...
    • Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase) 

      Sarre, Birta Ravdna Alexandersen; Dobrovolska, Olena; Lundström, Patrik; Turcu, Diana Cornelia; Agback, Tatiana; Halskau, Øyvind; Isaksson, Johan Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-30)
      Structural- and functional heterogeneity, as well as allosteric regulation, in homo-monomeric enzymes is a highly active area of research. One such enzyme is human nuclear-associated deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase), which has emerged as an interesting drug target in combination therapy with traditional nucleotide analogue treatment of cancer. We report, for the first time, ...
    • Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki 

      Schiffer, Philipp H.; Natsidis, Paschalis; Leite, Daniel J.; Robertson, Helen E.; Lapraz, François; Marlétaz, Ferdinand; Fromm, Bastian; Baudry, Liam; Simpson, Fraser; Høye, Eirik; Zakrzewski, Anne-Christin; Kapli, Paschalia; Hoff, Katharina J.; Müller, Steven; Marbouty, Martial; Marlow, Heather; Copley, Richard R.; Koszul, Romain; Sarkies, Peter; Telford, Maximilian J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-29)
      The evolutionary origins of Bilateria remain enigmatic. One of the more enduring proposals highlights similarities between a cnidarian-like planula larva and simple acoel-like flatworms. This idea is based in part on the view of the Xenacoelomorpha as an outgroup to all other bilaterians which are themselves designated the Nephrozoa (protostomes and deuterostomes). Genome data can provide important ...
    • Towards the design of a smart warehouse management system for spare parts management in the oil and gas sector 

      Khan, Natalia Batool; Solvang, Wei Deng; Yu, Hao; Rolland, Bente Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-25)
      Introduction: The oil and gas production industry requires rapid changing. As oil and gas companies around the world are called upon to decarbonize, several sectors within the industry are attempting to find new ways of working to achieve decarbonization. One of those sectors is spare parts warehousing. During the past decades of oil and gas production, spare parts warehousing has not been ...
    • Challenges and Strategies in Nursing Leadership: A Qualitative Study on Leaders in Mental Health Care 

      Lysfjord, Else Marie; Gjevjon, Edith Lillian Roth; Skarstein, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-10)
      Aim: To explore the challenges and strategies among new and experienced nursing leaders in mental healthcare; furthermore, to identify factors that support or hinder their leadership roles. Background: Strong nursing leadership is crucial for the quality of patient care and is associated with higher job security and better patient outcomes. Understanding what factors contribute to effective leadership ...
    • Utenfor, men likevel innenfor – snikende europeisk integrasjon på manglende kunnskapsgrunnlag 

      Breivik, Inger Litlehei (Mastergradsoppgave; Master thesis, 2024-11-01)
      Denne masteroppgaven har som sitt hovedanliggende å søke å fremstille et kunnskapsgrunnlag om europeiske integrasjon og den tilhørende integrasjonsprosessen, samt Norges tilknytningsforhold til Den europeiske union gjennom EØS-avtalen. Den europeiske union er et omfattende og komplekst institusjonelt og politisk system, og har stor innvirkning på stater på det europeiske kontinent. Dette gjelder ...
    • Ledere med ansatte på flere kontorsteder - En organisasjonsteoretisk litteraturstudie av styringsutfordringer ved avstandsledelse 

      Randa, Anne (Mastergradsoppgave; Master thesis, 2024-11-01)
      I denne oppgaven er de tre organisasjonsperspektivene som presenteres av Scott og Davis (2016), det rasjonelle, det naturlige, og det åpne perspektivet, benyttet for å undersøke styringsutfordringer ved avstandsledelse. Gjennom en litteraturstudie av relevant forskning har oppgaven undersøkt ulike styringsutfordringer og tiltak for å møte disse utfordringene, i offentlige organisasjoner i ...
    • Spenning mellom statlig styring og lokal makt under covid-19 pandemien 

      Elvrum, Vilde (Mastergradsoppgave; Master thesis, 2024-11-01)
      Hensikten med denne oppgaven er å se på spenningskonfliktene som kan oppstå mellom lokal makt og sentral makt i Norge. Disse spenningskonfliktene sees i lys av hva som utspilte seg i covid-19-pandemien som skjedde i årene 2020 til 2023. Oppgaven tar for seg hva slags arbeid kommuner og staten har i dag i Norge, og hvordan disse to enhetene opptrer i forhold til hverandre. Velferdsstaten i Norge har ...
    • Energiomstilling på Svalbard: En studie av energiomstillingen på Svalbard i perioden mellom Meld. St. 32 (2015 – 2016) og Meld. St. 26 (2023 – 2024) 

      Yürükel, Frida Mellem (Mastergradsoppgave; Master thesis, 2024-11-01)
      Tema for oppgaven er energiomstillingsprosessen på Svalbard i perioden fra fremleggelsen av Meld. St. 32 (2015 – 2016) frem til den nye «Svalbard-meldingen», Meld. St. 26 (2023 – 2024) ble lagt frem. Det argumenteres for at Meld. St. 32 (2015 – 2016) ble et startpunkt for visjonen om et nullutslippssamfunn på Svalbard, og videre belyses energiomstillingsprosessen fram til den nye meldingen ble fremmet ...
    • Research trends of acupressure from 2004 to 2024: A bibliometric and visualization analysis 

      Li, Zhi-qiang; Jiang, Mary Yue; Liu, Xue-han; Cai, Yi-qing; Wang, Chen-lu; Cao, Feng; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-29)
      Background - Acupressure has proven efficacy in symptoms management, making it valuable in clinical practice and patient care. Given the rising number of increasing publications on acupressure, we aimed to analyze the literature from the past 20 years and provided current trends and hotspot for future research directions.<p> <p>Methods - Publications on acupressure from January 1, 2004 through ...
    • Optimising Interannual Sea Ice Thickness Variability Retrieved From CryoSat-2 

      Nab, Carmen; Mallett, Robbie David Christopher; Nelson, Connor; Stroeve, Julienne; Tsamados, Michel (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-29)
      Satellite radar altimeters like CryoSat‐2 estimate sea ice thickness by measuring the returntime of transmitted radar pulses, reflected from the sea ice and ocean surface, to measure the radar freeboard. Converting freeboard to thickness requires an assumption regarding the fractional depth of the snowpack from which the radar waves backscatter (α). We derive sea ice thickness from CryoSat‐2 radar ...
    • Investigating the Norwegian eHealth Governance Model: Document Study 

      Linstad, Line Helen; Bjørnå, Hilde; Moen, Anne; Kristiansen, Truls Tunby; Hansen, Anne Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-04)
      Background: Governments and policy makers struggle to achieve a balance between hierarchical steering and horizontal governance in systems characterized by fragmented decision authority and multiple interests. To realize its One Citizen–One Journal eHealth policy vision, the Norwegian government established a special eHealth board of stakeholders to create an inclusive governance model that aligned ...
    • fair-calibrate v1.4.1: calibration, constraining, and validation of the FaIR simple climate model for reliable future climate projections 

      Smith, Christopher J.; Cummins, Donald; Fredriksen, Hege-Beate; Nicholls, Zebedee; Meinshausen, Malte; Allen, Myles; Jenkins, Stuart; Leach, Nicholas; Mathison, Camilla; Partanen, Antti-Ilari (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-03)
      Simple climate models (also known as emulators) have re-emerged as critical tools for the analysis of climate policy. Emulators are efficient and highly parameterised, where the parameters are tunable to produce a diversity of global mean surface temperature (GMST) response pathways to a given emission scenario. Only a small fraction of possible parameter combinations will produce historically ...
    • Work-leave rotation among general practitioners in Norwegian municipalities 

      Prestgaard, Erik Edvard; Fosse, Anette; Abelsen, Birgit; Harbitz, Martin Bruusgaard (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-19)
      Bakgrunn - Flere kommuner har innført rotasjonsordning (nordsjøturnus) for allmennleger, der legene gjennom året veksler mellom arbeidsperioder og friperioder. Vi har undersøkt utbredelsen av, årsaker til, innhold i og erfaringer med denne arbeidsformen.<p> <p>Materiale og metode - Vi har gjennomført en flerkasusstudie med data fra Statistisk sentralbyrå, fastlegeregisteret, kommunale dokumenter, ...
    • Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate 

      Nakano, Felipe Kenji; Åkesson, Anna; de Boer, Jasper; Dedja, Klest; D’hondt, Robbe; Haredasht, Fateme Nateghi; Björk, Jonas; Courbebaisse, Marie; Couzi, Lionel; Ebert, Natalie; Eriksen, Bjørn Odvar; Dalton, R. Neil; Derain-Dubourg, Laurence; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Jacquemont, Lola; Hansson, Magnus; Kamar, Nassim; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla; Åsling-Monemi, Kajsa; Selistre, Luciano; Larsson, Anders; Nyman, Ulf; Lanot, Antoine; Pottel, Hans; Delanaye, Pierre; Vens, Celine (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-02)
      In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible ...
    • Individuelle forutsetninger i hørelære 

      Eide, Renate Ørnes (Mastergradsoppgave; Master thesis, 2024-10-31)
      Denne studien har hatt som mål å undersøke følgende problemstilling: Hvordan påvirker elevers individuelle forutsetninger deres prestasjon i hørelærerelaterte fag på musikklinjen i videregående skole? Individuelle forutsetninger har i denne studien omhandlet komponentene kunnskap, læringsstrategier og interesse. Komponentene springer ut fra Patricia Alexander sin modell for utvikling av ekspertise, ...