Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect of hypothermia enables circulation of cooled experimental animals to be interrupted for 1–2 h without creating harmful effects, while tolerance of circulation arrest in normothermia is between 4 and 5 min. This ...

Re-irradiation can be considered for local recurrence or new tumours adjacent to a previously irradiated site to achieve durable local control for patients with cancer who have otherwise few therapeutic options. With the use of new radiotherapy techniques, which allow for conformal treatment plans, image guidance, and short fractionation schemes, the use of re-irradiation for different sites is ...

Background/Aim: A validation of the recently published METSSS model (developed from a large US database) predicting survival after palliative radiotherapy was performed. METSSS includes age, sex, cancer type, localization of distant metastases, comorbidity, and radiotherapy site. Patients and Methods: Both 1- and 5-year survival was assessed in the validation cohort. Deviations between model-predicted ...

Background - Artificial intelligence (AI) has shown promising results for cancer detection with mammographic screening. However, evidence related to the use of AI in real screening settings remain sparse.<p> <p>Purpose - To compare the performance of a commercially available AI system with routine, independent double reading with consensus as performed in a population-based screening program. ...

Background - Morbidity and mortality increase as Fontan patients age into adulthood. Limited studies have examined cardiac magnetic resonance and echocardiographic parameters to predict death and transplantation in children after the Fontan operation. The aim of this study was to investigate echocardiographic parameters in adolescents and adults after Fontan operation, including myocardial mechanics ...

The Koutras–McIntosh family of metrics include conformally flat pp-waves and the Wils metric. It appeared in a paper of 1996 by Koutras–McIntosh as an example of a pure radiation spacetime without scalar curvature invariants or infinitesimal symmetries. Here we demonstrate that these metrics have no 'hidden symmetries', by which we mean Killing tensors of low degrees. For the particular case of Wils ...

In this paper we analyse how a municipality set out to integrate risk management throughout an organisation with more than 9000 employees in six divisions and over 100 sub-units. An objective was to ensure coherence in risk management related work conducted in various sub-units in the municipality. Being forerunners, those involved had to find their own way. We identify three focus areas of importance ...

The zinc metalloprotease pseudolysin (PLN) secreted from Pseudomonas aeruginosa degrades extracellular proteins to produce bacterial nutrition, and various types of PLN inhibitors have been developed to suppress the bacterial growth. However, as the structure of the ligand-binding pocket of PLN has large similarities to those of human matrix metalloproteinases (MMPs) and other human zinc metalloprotease, ...

The arithmetic mean/geometric mean inequality (AM/GM inequality) facilitates classes of nonnegativity certificates and of relaxation techniques for polynomials and, more generally, for exponential sums. Here, we present a first systematic study of the AM/GM-based techniques in the presence of symmetries under the linear action of a finite group. We prove a symmetry-adapted representation theorem and ...

Aim/Background - The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway.<p> <p>Patients and methods - Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel ...