Viser treff 9661-9680 av 36144

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
      Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.<p> <p>Methods In this exploratory sub-study of the ASSAIL-MI trial, we examined leukocyte differential counts and their relation to myocardial salvage and peak troponin T (TnT) in STEMI ...
    • Postglacial species arrival and diversity buildup of northern ecosystems took millennia 

      Alsos, Inger Greve; Rijal, Dilli Prasad; Ehrich, Dorothee; Karger, Dirk Nikolaus; Yoccoz, Nigel; Heintzman, Peter D.; Brown, Antony; Lammers, Youri; Pellissier, Loïc; Alm, Torbjørn; Bråthen, Kari Anne; Coissac, Eric; Merkel, Marie Føreid; Alberti, Adriana; Denoeud, France; Bakke, Jostein (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      What drives ecosystem buildup, diversity, and stability? We assess species arrival and ecosystem changes across 16 millennia by combining regional-scale plant sedimentary ancient DNA from Fennoscandia with near-complete DNA and trait databases. We show that postglacial arrival time varies within and between plant growth forms. Further, arrival times were mainly predicted by adaptation to temperature, ...
    • Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity 

      Søraas, Arne Vasli; Grødeland, Gunnveig; Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Fevang, Børre; Murphy, Sarah Louise Mikalsen; Huse, Camilla; Nygaard, Anders Benteson; Steffensen, Anne Katrine; Al-Baldawi, Huda; Holberg-Petersen, Mona; Andresen, Lise Lima; Ågnes, Camilla; Ranheim, Trine; Schanke, Ylva; Istre, Mette Stausland; Dahl, John Arne; Chopra, Adity; Dudman, Susanne; Kaarbø, Mari; Andersen, Jan Terje; Vaage, Eline Benno; Tran, Trung The; Vaage, John Torgils; Michelsen, Annika Elisabet; Müller, Fredrik; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Holter, Jan Cato; Lund-Johansen, Fridtjof (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p> <p>Methods: We measured inflammatory mediators, antibodies to the ...
    • The case for case in Putin’s speeches 

      Janda, Laura Alexis; Fidler, Masako; Cvrček, Václav; Obukhova, Anna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-25)
      Vladimir V. Putin has banned the use of the word ‘war’ to refer to the conflict in Ukraine. While one’s choice of words is deliberate and conscious, grammatical categories are obligatory and pivotal to signaling the roles notions have in a discourse. Over- and underrepresentation of grammatical cases can be identified by Keymorph Analysis, which measures deviations from corpus norms analogously to ...
    • Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure 

      Vergaro, Giuseppe; Gentile, Francesco; Aimo, Alberto; Januzzi, James L.; Richards, A. Mark; Lam, Carolyn S.P.; de Boer, Rudolf A.; Meems, Laura M.G.; Latini, Roberto; Staszewsky, Lidia; Anand, Inder S.; Cohn, Jay N.; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Brunner-La Rocca, Hans-Peter; Bayes-Genis, Antoni; Lupón, Josep; Yoshihisa, Akiomi; Takeishi, Yasuchika; Egstrup, Michael; Gustafsson, Ida; Gaggin, Hanna K.; Eggers, Kai M.; Huber, Kurt; Gamble, Greg D.; Ling, Lieng H.; Leong, Kui Toh Gerard; Yeo, Poh Shuah Daniel; Ong, Hean Yee; Jaufeerally, Fazlur; Ng, Tze P.; Troughton, Richard; Doughty, Robert N.; Devlin, Gerry; Lund, Mayanna; Giannoni, Alberto; Passino, Claudio; Emdin, Michele (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-05)
      Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NTproBNP) in women and men with chronic heart failure (HF).<p> <p>Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study ...
    • Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008 

      Azulay, Naomi; Bjørkholt Olsen, Roy; Nielsen, Christopher Sivert; Stubhaug, Audun; Jenssen, Trond Geir; Schirmer, Henrik; Frigessi, Arnoldo; Rosseland, Leiv Arne; Tronstad, Christian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-14)
      Both diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events and death. Measures of heart rate variability (HRV) can be used to monitor the activity of the autonomic nervous system (ANS), and there are strong indications that HRV can be used to study the progression of ANS-related diabetes complications. This study ...
    • Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer–the MetAction precision medicine study 

      Ree, Anne Hansen; Mælandsmo, Gunhild Mari; Flatmark, Kjersti; Russnes, Hege Elisabeth Giercksky; Casteneda, Monica Gomez; Aas, Eline (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)
      Background: Precision cancer medicine (PCM), frequently used for the expensive and often modestly efficacious off-label treatment with medications matched to the tumour genome of end-stage cancer, challenges healthcare resources. We compared the health effects, costs and cost-effectiveness of our MetAction PCM study with corresponding data from comparator populations given best supportive care ...
    • Automatic Detection of Low-Backscatter Targets in the Arctic Using Wide Swath Sentinel-1 Imagery 

      Cristea, Anca; Johansson, Malin; Doulgeris, Anthony Paul; Brekke, Camilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-12)
      Low backscatter signatures in synthetic aperture radar (SAR) imagery are characteristic to surfaces that are highly smooth and specular reflective of microwave radiation. In the Arctic, these typically represent newly formed sea ice, oil spills, and localized weather phenomena such as low wind or rain cells. The operational monitoring of low backscatter targets can benefit from a stronger integration ...
    • Hip fractures in Norway – Inequity in treatment and outcomes 

      Kjærvik, Cato (Doctoral thesis; Doktorgradsavhandling, 2022-11-11)
      Målet med forskningsprosjektet var å belyse variasjon i behandling og utfall etter hoftebrudd i Norge, kartlegge forklaringer på og konsekvensene av variasjon, vurdere risikofaktorer for død etter hoftebrudd og deres relative betydning. I tillegg ønsket man å vurdere overlevelsesmønsteret og estimere varigheten av overdødelighet etter hoftebrudd. Prosjektet var en observasjonsstudie ...
    • Criterion validity of the Saltin-Grimby Physical Activity Level Scale in adolescents. The Fit Futures Study 

      Beldo, Sigurd Klemetsen; Aars, Nils Abel; Christoffersen, Tore; Furberg, Anne-Sofie; Halvorsen, Peder Andreas; Hansen, Bjørge Hermann; Horsch, Alexander; Sagelv, Edvard Hamnvik; Syed, Shaheen; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)
      Background<p> <p>The Saltin-Grimby Physical Activity Level Scale (SGPALS) is commonly used to measure physical activity (PA) in population studies, but its validity in adolescents is unknown. This study aimed to assess the criterion validity of the SGPALS against accelerometry in a large sample of adolescents. A secondary aim was to examine the validity across strata of sex, body mass index (BMI), ...
    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)
      Background. Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 ...
    • CRISPR/Cas9 to Silence Long Non-Coding RNAs 

      Rosenlund, Ingrid A; Calin, George A.; Dragomir, Mihnea Paul; Knutsen, Erik (Chapter; Bokkapittel, 2021-06-24)
      Knock-out (KO) of long non-coding RNAs (lncRNAs) enables functional characterization of this still poorly described group of transcripts. One of the most efficient and simplest methods to achieve complete KO of a lncRNA is by employing CRISPR/Cas gene editing. As most lncRNAs are not well annotated, their individual functional regions are not defined, and the majority of the transcripts are not ...
    • Reciprocal relationships between personality disorders and eating disorders in a prospective 17-year follow-up study 

      Eielsen, Hanna Kristine Punsvik; Vrabel, KariAnne; Hoffart, Asle; Rø, Øyvind; Rosenvinge, Jan H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-10)
      <p><b>Objective</b> This study aimed to report the presence of categorical and dimensional personality disorders (PD) in adults with longstanding eating disorders (ED) over a period of 17 years and to investigate whether changes in PD predict changes in ED symptoms or vice versa. <p><b>Methods</b> In total, 62 of the 80 living patients (78% response rate) with anorexia nervosa (<i>n</i> ...
    • Differences in time-critical interventions and radiological examinations between adult and older trauma patients: A national register-based study 

      Cuevas-Østrem, Mathias; Wisborg, Torben; Røise, Olav; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      BACKGROUND<p> <p>Older trauma patients are reported to receive lower levels of care than younger adults. Differences in clinical management between adult and older trauma patients hold important information about potential trauma system improvement targets. The aim of this study was to compare prehospital and early in-hospital management of adult and older trauma patients, focusing on time-critical ...
    • Evidence of temperature control on mesopelagic fish and zooplankton communities at high latitudes 

      Chawarski, Julek; Klevjer, Thor A.; Coté, David; Geoffroy, Maxime (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-06)
      Across temperate and equatorial oceans, a diverse community of fish and zooplankton occupies the mesopelagic zone, where they are detectable as sound-scattering layers. At high latitudes, extreme day-night light cycles may limit the range of some species, while at lower latitudes communities are structured by dynamic ocean processes, such as temperature. Using acoustic and oceanographic ...
    • Norway: An Insider Outside - or an Outsider Inside - European Civil Justice 

      Nylund, Anna (Chapter; Bokkapittel, 2016-12-19)
      Norway has stood on the doorsteps of the European Union (then the European Communities (EC)) for more than four decades. In 1960, Norway became one of the seven original members of the European Free Trade Association (EFTA), a trade-blocalternative to the European Economic Community (EEC). The Norwegian people voted against EC-membership in 1972 and 1994. In the late 1980's, a plan to create a single ...
    • Conclusions and Outlook 

      Krans, Bart; Nylund, Anna (Chapter; Bokkapittel, 2016-12-19)
      The first and clear conclusion from the papers in this book is far from surprising: law of the European Union has impact on national civil procedure. This might concern primary EU law, secondary EU law, case law, fundamental legal principles or soft law instruments. At the same time, there seems to be significant variation on several aspects of the impact of EU law on national civil procedure law. ...
    • Word order and finiteness in acquisition: A study of English and Norwegian wh-questions 

      Westergaard, Marit (Chapter; Bokkapittel, 2016-08-25)
      Children acquiring languages such as English, German or Dutch typically go through a phase where they produce non-finite root clauses, often referred to as the Optional Infinitive (OI) stage. But there is a difference between English on the one hand and the other Germanic languages on the other with respect to the occurrence of non-finite wh-questions: while there is a high number of OIs in English ...
    • Mission Performance Trade-offs of Battery-powered sUAS 

      Hovenburg, Anthony Reinier; Johansen, Tor Arne; Storvold, Rune (Chapter; Bokkapittel, 2017-07-27)
      A sensitivity analysis is presented on the influence of the weight, altitude and speed of battery-powered sUAS on the resulting stall speed, endurance and range. To aid in the determination of the aircraft performance prior to flight, a method is being brought forth that quantifies the impact of these mission parameters. As a case study the P31015 sUAS is used. The P31015 is a concept model of a ...
    • Movie and TV Depictions of Autism Spectrum Disorder 

      Nordahl-Hansen, Anders; Øien, Roald A (Chapter; Bokkapittel, 2017-11-30)
      This chapter focuses on the topic of character portrayals with autism spectrum disorders (ASD) in film and TV-series. We address this topic by presenting research from the general psychiatric field before we discuss the research on portrayals of characters with ASD. We will also provide the reader with some examples of films and TV-series that have been given particular attention in the popular media ...