Munin: Recent submissions
Now showing items 22841-22860 of 37055
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Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)Background: Statin has been widely used to treat hyperlipidemia because of its high potency in decreasing cholesterol levels. The present study aimed to examine the lipid-lowering effect of rosuvastatin and the composition, diversity and species abundance of gut microbiome in association with rosuvastatin efficacy. <br> <br> TRIAL REGISTRATION: ChiCTR-ORC-17013212 at the First Affiliated Hospital ... -
Physical Conditions of Fast Glacier Flow: 3.Seasonally-Evolving Ice Deformation onStore Glacier, West Greenland
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)Temporal variations in ice sheet flow directly impact the internal structure within ice sheetsthrough englacial deformation. Large-scale changes in the vertical stratigraphy within ice sheets havebeen previously conducted on centennial to millennial timescales; however, intra-annual changes inthe morphology of internal layers have yet to be explored. Over a period of 2 years, we use autonomousphas ... -
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase associated with neuronal development and brain physiology. The DYRK kinases are very unusual with respect to the sequence of the catalytic loop, in which the otherwise highly conserved arginine of the HRD motif is replaced by a cysteine. This replacement, along with the proximity of a potential disulfide-bridge ... -
Brief Report: The Genetic Profile of Rheumatoid Factor–Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)<i><p>Objective</i>: Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)–positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF‐positive polyarticular JIA with those of RA and selected other ... -
Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)<i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ... -
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-02)<i><p>Background</i>: The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim of the present study was to develop a PAX6 knock out cell line as a tool for molecular studies of the roles PAX6 have in attenuating ... -
Impact of Arctic shelf summer stratification on Holocene climate variability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-21)Understanding the dynamic of freshwater and sea-ice export from the Arctic is crucial to better comprehend the potential near-future climate change consequences. Here, we report nitrogen isotope data of a core from the Laptev Sea to shed light on the impact of the Holocene Siberian transgression on the summer stratification of the Laptev Sea. Our data suggest that the oceanographic setting was ... -
Gruppeforskjeller i spatiale evner. En kvantitativ studie av gruppeforskjeller i spatiale evner mellom fysikkstudenter og psykologistudenter
(Master thesis; Mastergradsoppgave, 2018-04-30)Forskning har indikert kjønnsforskjeller i spatiale evner, i tillegg til gruppeforskjeller mellom studentgrupper. Menn presterer bedre på spatiale oppgaver enn kvinner, og «STEM»-studenter har vist seg å prestere bedre enn andre studenter. På bakgrunn av tidligere forskning ønsket vi å teste hypotesen om at fysikkstudenter presterer bedre på spatiale tester enn psykologistudenter. Femti deltakere ... -
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-19)There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully elucidated. This study examined the effects of C5 in normal hemostasis and in <i>Escherichia coli</i>‐induced coagulation and tissue factor (TF) up‐regulation. Fresh whole blood ... -
Benthic-pelagic trophic coupling in an Arctic marine food web along vertical water mass and organic matter gradients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-26)Understanding drivers of benthic-pelagic coupling in Arctic marine ecosystems is key to identifying benthic areas that may be sensitive to climate-driven changes in hydrography and surface production. We coupled algal biomass and sedimentary characteristics with stable isotope data for 113 fishes and invertebrates in the Canadian Beaufort Sea and Amundsen Gulf to examine how trophic structure was ... -
High-resolution landform assemblage along a buried glacio-erosive surface in the SW Barents Sea revealed by P-Cable 3D seismic data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-01)The Quaternary sedimentary record in the Arctic captures a diverse and evolving range of landscapes reflecting cli-mate changes. Here we study the geological landform assemblage of the Upper Regional Unconformity (URU) in theSW Barents Sea. The aims are (i) to characterize buried geological landforms on a meter-scale resolution, (ii) to un-derstand their link with underlying structures, and (iii) ... -
New occurrences of Palaeopascichnus from the Stáhpogieddi Formation, Arctic Norway, and their bearing on the age of the Varanger Ice Age.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-18)We report on new occurrences of the late Ediacaran problematicum <i>Palaeopascichnus</i> (Protista?) from the Stáhpogieddi Formation, Arctic Norway. The stratigraphically lowest occurrences are in beds transitional between the Lillevannet and Indreelva members: the highest in the second cycle of the Manndrapselva Member, stratigraphically close to the lowest occurrences of Cambrian-type trace fossils. ... -
APC mosaicism in a young woman with desmoid type fibromatosis and familial adenomatous polyposis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-24)Familial adenomatous polyposis (FAP) is usually caused by germline mutations in the adenomatous polyposis coli (APC) gene. The classic form is characterized by hundreds to thousands of adenomas in the colorectum and early onset colorectal cancer (CRC) if left untreated. FAP is also associated with multiple extra-colonic manifestations such as gastroduodenal polyps, osteomas, epidermoid cysts, fibromas ... -
Review of Icing Effects on Wind Turbine in Cold Regions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-05)This paper describes a brief overview of main issues related to atmospheric ice accretion on wind turbines installed in cold climate region. Icing has significant effects on wind turbine performance particularly from aerodynamic and structural integrity perspective, as ice accumulates mainly on the leading edge of the blades that change its aerodynamic profile shape and effects its structural dynamics ... -
Linking interprofessional work to outcomes for employees: A meta‐analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-14)The aim of this meta‐analysis of studies of workers in the health and social care sector was to examine the relationship between interprofessional work and employee outcomes of job stress, autonomy, burnout, engagement, job satisfaction, turnover intention, and perceived service quality, and to examine the influence of different moderators on those relationships. A systematic literature search of ... -
Deglacial dynamics of the Vestfjorden - Trænadjupet palaeo-ice stream, northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-18)Few well‐dated records of the deglacial dynamics of the large palaeo‐ice streams of the major Northern Hemisphere ice sheets are presently available, a prerequisite for an improved understanding of the ice‐sheet response to the climate warming of this period. Here we present a transect of gravity‐core samples through Trænadjupet and Vestfjorden, northern Norway, the location of the Trænadjupet – ... -
Timing of eating across ten European countries - Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)<p><i>Objective</i>: To examine timing of eating across ten European countries.</p> <p><i>Design</i>: Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995–2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption ... -
A successful new method for single left lobe recruitment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-18)Any gas will flow down the path of least resistance and highest compliance. This is a problem in the treatment of severe unilateral lung disease in the intensive care unit (ICU). Deep sedation interferes with the diaphragm’s ability to distribute air into the lower lung. Spontaneous breathing in a conscious patient, in combination with mechanical ventilation via an endotracheal tube inserted into ... -
Non-Oberbeck-Boussinesq zonal flow generation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)Novel mechanisms for zonal flow (ZF) generation for both large relative density fluctuations and background density gradients are presented. In this non-Oberbeck–Boussinesq (NOB) regime ZFs are driven by the Favre stress, the large fluctuation extension of the Reynolds stress, and by background density gradient and radial particle flux dominated terms. Simulations of a nonlinear full-F gyro-fluid ... -
Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)<p><i>Background</i>: Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment between recipients and non-recipients of chemotherapy, and describe metabolite profiles associated with treatment-related weight gain.</p> <p><i>Methods</i>: This ...