Large amounts of methane are stored in continental margins as gas hydrates. They are stable under high pressure and low, but react sensitively to environmental changes. Bottom water temperature and sea level changes were considered as main contributors to gas hydrate dynamics after the last glaciation. However, here we show with numerical simulations that pulses of increased sedimentation dominantly ...

The study of the network design problems related to reverse supply chain and reverse logistics is of great interest for both academicians and practitioners due to its important role for a sustainable society. However, reverse logistics network design is a complex decision-making problem that involves several interactive factors and faces many uncertainties. Thus, in order to improve the reverse ...

Objectives: <br> Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize with immune-checkpoint inhibitors. While the roles of CAFs in cancer development are well described, their immune-regulatory properties remain incompletely understood. This study investigates correlations between CAF and immune-markers in tumor stroma from nonsmall cell lung cancer (NSCLC) ...

: The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector ...

Background: <br>Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and may cause harm. C-reactive protein (CRP) is an acute-phase biomarker that can be rapidly measured at the point of care and may predict benefit from antibiotic treatment in AECOPD. It is not clear ...

The Norwegian Armed Forces have made major changes to the enlistment and selection system for conscripts in recent years. In this paper, the predictive validity of various selection criteria for Military Performance is examined. The sample consisted of 3,276 conscripts, of whom 18 percent were female. The predictors in the analysis were General Mental Ability, Self-Perceived Physical Fitness, ...

This paper mainly aims at evaluating capabilities of derivation of ionospheric conductivities using two principal auroral emissions (427.8 and 630 nm). We have evaluated a photometric method of derivation of ionospheric conductivities based on simultaneous observations of a photometer (feld of view = ~1.2°), a digital camera, and the EISCAT UHF radar (feld of view = ~0.7°) operated at Tromsø, ...

A stochastic nonlinear model predictive controller (SNMPC) is designed for automatic generator control of a proxy of the Nordic power system, and it is compared with a multi-stage nonlinear model predictive controller (MNMPC). Both controllers are scenario based, but originate in two different disturbance modeling paradigms; stochastic and deterministic. A simulation study indicates that the two ...

The goal of this work was to identify sequences encoding monooxygenase biocatalysts with novel features by in silico mining an assembled metagenomic dataset of polar and subpolar marine sediments. The targeted enzyme sequences were Baeyer–Villiger and bacterial cytochrome P450 monooxygenases (CYP153). These enzymes have wide-ranging applications, from the synthesis of steroids, antibiotics, mycotoxins ...

The most popular technique, so far, for biomass waste to energy conversion has been incineration, but this technique has raised a lot of objection among nature activists due to the release of particulate matter and pollutants like nitrogen oxides (NOx) into the atmosphere. However, advanced non-incineration conversion methods like pyrolysis, thermal gasification, and plasma-arc gasification are ...