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dc.contributor.authorBerg, Vivian
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorPettersen, Rolf Dagfinn
dc.contributor.authorHansen, Solrunn
dc.contributor.authorVeyhe, Anna Sofia
dc.contributor.authorJorde, Rolf
dc.contributor.authorOdland, Jon Øyvind
dc.contributor.authorSandanger, Torkjel M
dc.date.accessioned2017-02-21T14:06:39Z
dc.date.available2017-02-21T14:06:39Z
dc.date.issued2017-01
dc.description.abstractBackground:<br>Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.<br> Objectives:<br>We investigated the association between POPs and thyroid-stimulating hormone (TSH) and thyroid hormones (THs) in mother and child pairs from the Northern Norway Motherand- Child Contaminant Cohort Study (MISA).<br> Methods:<br>Nineteen POPs and 10 thyroid parameters were analyzed in serum from 391 pregnant women in their second trimester. In addition, TSH concentrations in heel-prick samples from the infants were analyzed by the Norwegian Newborn Screening program. Association studies with a multipollutant approach were performed using multivariate analyses; partial least squares (PLS) regression, hierarchical clustering, and principal component analysis (PCA).<br> Results:<br>Several POPs were significantly associated with TSH and THs: a) PFOS was positively associated with TSH; b) PCBs, HCB, and nonachlors were inversely associated with T3, T4, and FT4; and, c) PFDA and PFUnDA were inversely associated with T3 and FT3. After mutual adjustments for the other contaminants, only PFDA and PFUnDA remained significantly associated with T3 and FT3, respectively. Infants born to mothers within the highest TSH quartile had 10% higher mean concentrations of TSH compared with children born to mothers in the lowest TSH quartile.<br> Conclusion:<br>The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regard to maternal and infant thyroid function.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1289/EHP152>doi: 10.1289/EHP152.</a><br>Reproduced with permission from Environmental Health Perspectives.en_US
dc.identifier.citationBerg V, Nøst TH, Pettersen RD, Hansen S, Veyhe AS, Jorde r, Odland j, Sandanger TM. Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment. Environmental Health Perspectives. 2016;125(1):127-133en_US
dc.identifier.cristinIDFRIDAID 1450437
dc.identifier.doi10.1289/EHP152
dc.identifier.issn0091-6765
dc.identifier.issn1552-9924
dc.identifier.urihttps://hdl.handle.net/10037/10331
dc.language.isoengen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.journalEnvironmental Health Perspectives
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titlePersistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessmenten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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