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dc.contributor.authorBerndt, Sonja I.
dc.contributor.authorCamp, Nicola J.
dc.contributor.authorSkibola, Christine F.
dc.contributor.authorVijai, Joseph
dc.contributor.authorWang, Zhaoming
dc.contributor.authorGu, Jian
dc.contributor.authorNieters, Alexandra
dc.contributor.authorKelly, Rachel S
dc.contributor.authorSmedby, Karin E.
dc.contributor.authorMonnereau, Alain
dc.contributor.authorCozen, Wendy
dc.contributor.authorCox, Angela
dc.contributor.authorWang, Sophia S.
dc.contributor.authorLan, Qing
dc.contributor.authorTeras, Lauren R
dc.contributor.authorMachado, Moara
dc.contributor.authorYeager, Meredith
dc.contributor.authorBrooks-Wilson, Angela R.
dc.contributor.authorHartge, Patricia
dc.contributor.authorPurdue, Mark P.
dc.contributor.authorBirmann, Brenda M.
dc.contributor.authorVajdic, Claire M.
dc.contributor.authorCocco, Pierluigi
dc.contributor.authorZhang, Yawei
dc.contributor.authorGiles, Graham G.
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorLawrence, Charles
dc.contributor.authorMontalvan, Rebecca
dc.contributor.authorBurdett, Laurie
dc.contributor.authorHutchinson, Amy
dc.contributor.authorYe, Yuanqing
dc.contributor.authorCall, Timothy G.
dc.contributor.authorShanafelt, Tait D.
dc.contributor.authorNovak, Anne J.
dc.contributor.authorKay, Neil E.
dc.contributor.authorLiebow, Mark
dc.contributor.authorCunningham, Julie M.
dc.contributor.authorAllmer, Cristine
dc.contributor.authorHjalgrim, Henrik
dc.contributor.authorAdami, Hans-Olov
dc.contributor.authorMelbye, Mads
dc.contributor.authorGlimelius, Bengt
dc.contributor.authorChang, Ellen T.
dc.contributor.authorGlenn, Martha
dc.contributor.authorCurtin, Karen
dc.contributor.authorCannon-Albright, Lisa A.
dc.contributor.authorDiver, W Ryan
dc.contributor.authorLink, Brian K.
dc.contributor.authorWeiner, George J.
dc.contributor.authorConde, Lucia
dc.contributor.authorBracci, Paige M.
dc.contributor.authorRiby, Jacques
dc.contributor.authorArnett, Donna K.
dc.contributor.authorZhi, Degui
dc.contributor.authorLeach, Justin M.
dc.contributor.authorHolly, Elizabeth A.
dc.contributor.authorJackson, Rebecca D.
dc.contributor.authorTinker, Lesley F.
dc.contributor.authorBenavente, Yolanda
dc.contributor.authorSala, Nuria
dc.contributor.authorCasabonne, Delphine
dc.contributor.authorBecker, Nikolaus
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorBrennan, Paul
dc.contributor.authorForetova, Lenka
dc.contributor.authorMaynadie, Marc
dc.contributor.authorMcKay, James
dc.contributor.authorStaines, Anthony
dc.contributor.authorChaffee, Kari G.
dc.contributor.authorAchenbach, Sara J.
dc.contributor.authorVachon, Celine M.
dc.contributor.authorGoldin, Lynn R.
dc.contributor.authorStrom, Sara S.
dc.contributor.authorLeis, Jose F.
dc.contributor.authorWeinberg, J. Brice
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorNorman, Aaron D.
dc.contributor.authorDe Roos, Anneclaire J.
dc.contributor.authorMorton, Lindsay M.
dc.contributor.authorSeverson, Richard K.
dc.contributor.authorRiboli, Elio
dc.contributor.authorVineis, Paolo
dc.contributor.authorKaaks, Rudolph
dc.contributor.authorMasala, Giovanna
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorVermeulen, Roel C.H.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorMilne, Roger L.
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorWeinstein, Stephanie
dc.contributor.authorClavel, Jacqueline
dc.contributor.authorZheng, Tongzhang
dc.contributor.authorHolford, Theodore R.
dc.contributor.authorVillano, Danylo J.
dc.contributor.authorMaria, Ann
dc.contributor.authorSpinelli, John J.
dc.contributor.authorGascoyne, Randy D.
dc.contributor.authorConnors, Joseph M.
dc.contributor.authorBertrand, Kimberly A.
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorKraft, Peter
dc.contributor.authorKricker, Anne
dc.contributor.authorTurner, Jenny
dc.contributor.authorEnnas, Maria Grazia
dc.contributor.authorFerri, Giovanni M.
dc.contributor.authorMiligi, Lucia
dc.contributor.authorLiang, Liming
dc.contributor.authorMa, Baoshan
dc.contributor.authorHuang, Jinyan
dc.contributor.authorCrouch, Simon
dc.contributor.authorPark, Ju-Hyun
dc.contributor.authorChatterjee, Nilanjan
dc.contributor.authorNorth, Kari E.
dc.contributor.authorSnowden, John A.
dc.contributor.authorWright, Josh
dc.contributor.authorFraumeni, Joseph F.
dc.contributor.authorOffit, Kenneth
dc.contributor.authorWu, Xifeng
dc.contributor.authorDe Sanjose, Silvia
dc.contributor.authorCerhan, James R.
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorSlager, Susan L.
dc.date.accessioned2017-02-28T14:22:36Z
dc.date.available2017-02-28T14:22:36Z
dc.date.issued2016-03-09
dc.description.abstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P<5 × 10−7) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10−8) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10−7). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1038/ncomms10933>doi: 10.1038/ncomms10933</a>en_US
dc.identifier.citationBerndt, S. I. et al. Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nat. Commun. 7:10933 doi: 10.1038/ncomms10933 (2016).en_US
dc.identifier.issn2041-1723
dc.identifier.otherFRIDAID 1370533
dc.identifier.other10.1038/ncomms10933
dc.identifier.urihttp://hdl.handle.net/10037/10392
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalNature Communications
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleMeta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemiaen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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