Vis enkel innførsel

dc.contributor.authorGallo, Valentina
dc.contributor.authorVanacore, Nicola
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorVermeulen, Roel
dc.contributor.authorBrayne, Carol
dc.contributor.authorPearce, Neil
dc.contributor.authorWark, Petra A
dc.contributor.authorWard, Heather A
dc.contributor.authorFerrari, Pietro
dc.contributor.authorJenab, Mazda
dc.contributor.authorAndersen, Peter M
dc.contributor.authorWennberg, Patrik
dc.contributor.authorWareham, Nicholas
dc.contributor.authorKatzke, Verena
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorPeeters, Petra H
dc.contributor.authorMattiello, Amalia
dc.contributor.authorPala, Valeria
dc.contributor.authorBarricante, Aurelio
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorTravier, Noemie
dc.contributor.authorTravis, Ruth C
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorPessah-Rasmussen, Helene
dc.contributor.authorPetersson, Jesper
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTumino, Rosario
dc.contributor.authorQuiros, Jose Ramon
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKyrozis, Andreas
dc.contributor.authorOikonomidou, Despoina
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorArriola, Larraitz
dc.contributor.authorBoeing, Heiner
dc.contributor.authorVigl, Matthaeus
dc.contributor.authorClaver-Chapelon, Francoise
dc.contributor.authorMiddleton, Lefkos
dc.contributor.authorRiboli, Eilo
dc.contributor.authorVineis, Paolo
dc.date.accessioned2017-03-11T09:40:00Z
dc.date.available2017-03-11T09:40:00Z
dc.date.issued2016-03-11
dc.description.abstractPrevious case–control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42–1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased—not increased like in case–control studies—risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.en_US
dc.description.sponsorshipThis research has been made possible thanks to a grant of the European Community (5th Framework Programme) to Prof. Paolo Vineis (Grant QLK4CT199900927); and a grant of the Compagnia di San Paolo to the ISI Foundation. All authors are independent form founders. Mortality data from the Netherlands are obtained from “Statistics Netherlands”. In addition we would like to thank for their financial support: Europe Against cancer Program of the European Commission (SANCO); ISCIII, Red de Centros RCESP, C03/09; Spanish Ministry of Health (ISCIII RETICC RD06/0020); Deutsche Krebshilfe; Deutsches Krebsforschungszentrum; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; Spanish Ministry of Health (ISCIII RETICC RD06/0020)Cancer Research UK; Medical Research Council, United Kingdom; Stroke Association, United Kingdom; British Heart Foundation; Department of Health, United Kingdom; Food Standards Agency, United Kingdom; Wellcome Trust, United Kingdom Greek Ministry of Health; Greek Ministry of Education; Italian Association for Research on Cancer (AIRC); Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Statistics Netherlands (The Netherlands); Swedish Cancer; Swedish Scientific Council; Regional Government of Skåne and Västerbotten, Sweden; Norwegian Cancer Society; Research Council of Norway; French League against cancer, Inserm, Mutuelle Generale l’Education National and IGR.en_US
dc.descriptionSource: <a href=http://dx.doi.org/10.1007/s10654-016-0119-9>doi: 10.1007/s10654-016-0119-9</a>en_US
dc.identifier.citationGallo, V., Vanacore, N., Bueno-de-Mesquita, H.B. et al. Eur J Epidemiol (2016) 31: 255. doi:10.1007/s10654-016-0119-9en_US
dc.identifier.cristinIDFRIDAID 1366303
dc.identifier.doi10.1007/s10654-016-0119-9
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.urihttps://hdl.handle.net/10037/10572
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalEuropean Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.titlePhysical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel