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The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study

Permanent link
https://hdl.handle.net/10037/10603
DOI
https://doi.org/10.1136/jech-2015-206776
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Date
2016-08-25
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Strand, Bjørn Heine; Cooper, Rachel; Bergland, Astrid; Jørgensen, Lone; Schirmer, Henrik; Skirbekk, Vegard; Emaus, Nina
Abstract
Background Grip strength has consistently been found to predict all-cause mortality rates. However, few studies have examined cause-speci fi c mortality or tested age differences in these associations. Methods In 1994, grip strength was measured in the population-based Tromsø Study, covering the ages 50 – 80 years (N=6850). Grip strength was categorised into fi fths, and as z-scores. In this cohort study, models with all-cause mortality and deaths from speci fi c causes as the outcome were performed, strati fi ed by sex and age using Cox regression, adjusting for lifestyle-related and health-related factors. Results During 17 years of follow-up, 2338 participants died. A 1 SD reduction in grip strength was associated with HR=1.17 (95% CI 1.12 to 1.22) for all- cause mortality in a model adjusted for age, gender and body size. This association was similar across all age groups, in men and women, and robust to adjustment for a range of lifestyle-related and health-related factors. Results for deaths due to cardiovascular disease (CVD), respiratory diseases and external causes resembled those for all-cause mortality, while for cancer, the association was much weaker and not signi fi cant after adjustment for lifestyle-related and health-related factors. Conclusions Weaker grip strength was associated with increased all-cause mortality rates, with similar effects on deaths due to CVD, respiratory disease and external causes, while a much weaker association was observed for cancer-related deaths. These associations were similar in both genders and across age groups, which supports the hypothesis that grip strength might be a biomarker of ageing over the lifespan.
Description
Source:http://jech.bmj.com/content/70/12/1214
Publisher
BMJ Publishing Group. Journal of Epidemiol Community Health
Citation
Strand BH, Cooper R, Bergland A, Jørgensen l, Schirmer H, Skirbekk V, Emaus N. The association of grip strength from midlife onwards with all-cause and cause-specific mortality over 17 years of follow-up in the Tromsø Study. Journal of Epidemiology and Community Health. 2016;70(12):1214-1221
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