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Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anticancer, Anti-Diabetes, and Antibacterial Activities

Permanent link
https://hdl.handle.net/10037/10627
DOI
https://doi.org/10.3389/fmars.2016.00068
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Date
2016-05-10
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Lauritano, Chiara; Andersen, Jeanette hammer; Hansen, Espen; Albrigtsen, Marte; Escalera, Laura; Esposito, Francesco; Helland, Kirsti; Østnes Hanssen, Kine; Romano, Giovanna; Ianora, Adrianna
Abstract
Marine microalgae are considered a potentially new and valuable source of biologically active molecules for applications in the food industry as well as in the pharmaceutical, nutraceutical, and cosmetic sectors. They can be easily cultured, have short generation times and enable an environmentally-friendly approach to drug discovery by overcoming problems associated with the over-utilization of marine resources and the use of destructive collection practices. In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. In addition, for three diatoms we also tested two different clones to disclose diversity in clone bioactivity. Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis) activities whereas, none of the other microalgae were bioactive against the conditions tested for. Furthermore, none of the 6 diatom species tested were toxic on normal human cells. Culturing conditions (i.e., nutrient starvation conditions) greatly influenced bioactivity of the majority of the clones/species tested. This study denotes the potential of diatoms as sources of promising bioactives for the treatment of human pathologies.
Description
Published version. Source at https://doi.org/10.3389/fmars.2016.00068
Publisher
Frontiers Media
Citation
Lauritano C. et.al.: Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anticancer, Anti-Diabetes, and Antibacterial Activities . Frontiers in Marine Science. 2016;3
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